Korean J Pathol.  2014 Apr;48(2):151-158.

Different Protein Expressions between Peripheral Ameloblastoma and Oral Basal Cell Carcinoma Occurred at the Same Mandibular Molar Area

• Kim YS
• Lee SK

Abstract

Peripheral ameloblastoma (PA) in gingiva is rare and often confused with oral basal cell carcinoma (OBCC). The tissues of one case of PA and one case of OBCC with the same mandibular molar area affected were compared via an immunohistochemical examination using 50 antisera. The PA and OBCC showed similar proliferation of basaloid epithelial strands, but toluidine blue staining revealed that the PA had pinkish juxta-epithelial myxoid tissue, whereas the OBCC was infiltrated by many mast cells. Immunohistochemical comparisons showed that the PA was strongly positive for ameloblastin, KL1, p63, carcinoembryonic antigen, focal adhesion kinase, and cathepsin K, and slightly positive for amelogenin, Krox-25, E-cadherin, and PTCH1, whereas the OBCC was not. On the other hand, the OBCC was strongly positive for EpCam, matrix metalloprotease (MMP)-1, alpha1-antitrypsin, cytokeratin-7, p53, survivin, pAKT1, transforming growth factor-beta1, NRAS, TGase-1, and tumor nescrosis factor-alpha, and consistently positive for beta-catenin, MMP-2, cathepsin G, TGase-2, SOS-1, sonic hedgehog, and the beta-defensins-1, -2, -3, while the PA was not. These data suggest that the tumorigeneses of PA and OBCC differ, and that PAs undergo odontogenic differentiation and generate oncogenic signals for infiltrative growth and bone resorption, whereas OBCCs undergo basaloid epidermal differentiation as a result of growth factor/cytokine-related oncogenic signals.

Keyword

Peripheral ameloblastoma; Carcinoma, basal cell; Immunohistochemistry

MeSH Terms

Ameloblastoma*
Amelogenin
beta Catenin
Bone Resorption
Cadherins
Carcinoembryonic Antigen
Carcinogenesis
Carcinoma, Basal Cell*
Cathepsin G
Cathepsin K
Focal Adhesion Protein-Tyrosine Kinases
Gingiva
Hand
Hedgehogs
Immune Sera
Immunohistochemistry
Keratin-7
Mast Cells
Molar*
Tolonium Chloride
Amelogenin
Cadherins
Carcinoembryonic Antigen
Cathepsin G
Cathepsin K
Focal Adhesion Protein-Tyrosine Kinases
Immune Sera
Keratin-7
Tolonium Chloride
beta Catenin