Korean J Otolaryngol-Head Neck Surg.
1999 Dec;42(12):1514-1519.
Expression and Role of Adhesion Molecules in the Nasal Mucosa of the Rat with Experimentally Induced Allergic Rhinitis
- Affiliations
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- 1Department of Otorhinolaryngology-Head and Neck Surgery Seoul National University College of Medicine, Seoul, Korea. ygmin@plaza.snu.ac.kr
- 2Department of Otorhinolaryngology, Inje University, Sanggye Paik Hospital, Seoul, Korea.
- 3Department of Otorhinolaryngology, Hallym University, College of Medicine, Seoul, Korea.
Abstract
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BACKGROUND AND OBJECTIVES: Airway allergic reactions are induced by infiltrating inflammatory cells into the human airway tissues through interactions between vascular endothelial cells, inflammatory mediators and adhesion molecules. Accordingly, it is important to study the role of adhesion molecules for the evaluation of pathophysiology of allergy. The aim of this study is to investigate the effect of monoclonal antibodies against intercellular adhesion molecule-1 (ICAM-1) and leukocyte function associated molecule-1 (LFA-1) on the pathophysiology of allergy in ovalbumin-sensitized rats.
MATERIALS AND METHODS
We developed an allergy model in rat using the intraperitoneal injection and intranasal nebulization of ovalbumine solution. We evaluated in vivo effects of ICAM-1 and LFA-1 monoclonal antibodies on the expression of ICAM-1 and LFA-1 in ovalbumin sensitized rats.
RESULTS
Nasal symptoms after allergen challenge were significantly suppressed and the number of eosinophil in nasal mucosa were significantly inhibited by the treatment of adhesion molecule antibodies. Anti-ICAM-1 and anti-LFA-1 monoclonal antibodies suppressed the expression of ICAM-1 and LFA-1 in nasal mucosa of ovalbumin-sensitized rats.
CONCLUSION
It is suggested that allergy can be managed by a useful treatment method using adhesion molecule antibody.
MeSH Terms
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Animals
Antibodies
Antibodies, Monoclonal
Endothelial Cells
Eosinophils
Humans
Hypersensitivity
Injections, Intraperitoneal
Intercellular Adhesion Molecule-1
Leukocytes
Lymphocyte Function-Associated Antigen-1
Nasal Mucosa*
Ovalbumin
Rats*
Rhinitis*
Antibodies
Antibodies, Monoclonal
Intercellular Adhesion Molecule-1
Lymphocyte Function-Associated Antigen-1
Ovalbumin
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