Endocrinol Metab.  2013 Sep;28(3):207-213. 10.3803/EnM.2013.28.3.207.

Variation in Serum Creatinine Level Is Correlated to Risk of Type 2 Diabetes

• Moon JS
• Lee JE
• Yoon JS

• KMID: 1973825
• DOI: http://doi.org/10.3803/EnM.2013.28.3.207

Abstract

BACKGROUND
Skeletal muscle is well established as a major target organ of insulin action, and is associated with the pathogenesis of type 2 diabetes. Therefore, we attempted to determine whether a variation in serum creatinine is related to the development of type 2 diabetes and other risk factors for diabetes.
METHODS
A total of 2,676 nondiabetic subjects with stable and normal renal function (estimated glomerular filtration rate >60 mL/min/1.73 m2) were followed up for approximately 4.5 years. New onset diabetes was defined as fasting plasma glucose (FPG) > or =7.0 mmol/L, glycated hemoglobin (HbA1c) > or =6.5%, or subjects taking antidiabetic agents. Variation of serum creatinine (DeltaCre) was defined as a difference between follow-up and baseline creatinine. In subgroup analysis, body composition was examined by bioelectric impedance analysis method.
RESULTS
A total of 106 subjects were diagnosed with new-onset diabetes during the follow-up period. Baseline serum creatinine was not different between the new-onset diabetes and no diabetes groups. Negative DeltaCre (DeltaCre <0) showed an association with increased risk of type 2 diabetes after adjusting for age, sex, body mass index, systolic blood pressure, FPG, HbA1c, triglyceride, high density lipoprotein cholesterol, and gamma-glutamyl transpeptidase (odds ratio, 1.885; 95% confidence interval, 1.127 to 3.153). Serum creatinine level demonstrated positive correlation with muscle mass and negative correlation with percentage of body fat in body composition analysis.
CONCLUSION
Serum creatinine reflected body muscle mass and the decrease of serum creatinine might be regarded as a risk factor for type 2 diabetes.

Keyword

Diabetes mellitus; Risk factors; Creatinine; Muscle mass

MeSH Terms

Adipose Tissue
Blood Pressure
Body Composition
Body Mass Index
Cholesterol
Cholesterol, HDL
Creatinine
Diabetes Mellitus
Electric Impedance
Fasting
Follow-Up Studies
gamma-Glutamyltransferase
Glomerular Filtration Rate
Glucose
Hemoglobins
Hypoglycemic Agents
Insulin
Lipoproteins
Muscle, Skeletal
Muscles
Plasma
Risk Factors
Cholesterol
Cholesterol, HDL
Creatinine
Glucose
Hemoglobins
Hypoglycemic Agents
Insulin
Lipoproteins
gamma-Glutamyltransferase

Figure

• 

  Fig. 1 Correlation between serum creatinine level, (A) muscle mass, (B) lean body mass, and (C) percentage of body fat tissue by linear regression analysis with 95% mean prediction interval.

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