Tuberc Respir Dis.  2002 Oct;53(4):431-438. 10.4046/trd.2002.53.4.431.

The Usefulness and Safety of Natural Stent in a Canine Model of Tracheal Stenosis

• Kim HJ
• Koh WJ
• Suh GY
• Chung MP
• Kim JG
• Suh SW
• Kwon OJ

• KMID: 1970600
• DOI: http://doi.org/10.4046/trd.2002.53.4.431

Abstract

BACKGROUND: In order to investigate the usefulness and safety of Natural Stent, we performed this study in a canine model of tracheal stenosis induced using Nd-YAG laser.
METHODS
After tracheal stenosis was induced in 12 Mongrel dogs using Nd-YAG laser, either Dumon (n=6) or Natural (n=6) stent was inserted into the trachea. To assess the degree of stent migration and mucostasis, bronchoscopy was performed every week for 4 weeks, after which all stents were removed. One week after stent removal, tracheal stenosis was evaluated by bronchoscopy.
RESULTS
The degree of stent migration was not different between the dogs with Dumon stent (3.0+/-0.8) and those with Natural (2.0+/-1.0), nor was the degree of mucostasis, at Dumon (1.7+/-0.5) and Natural Stent (1.5+/-0.6), respectively. One week after stent removal, the degree of tracheal stenosis was not different between the Dumon (1.5+/-0.5) and the Natural group (1.0+/-0.4). In addition, there was no death and the degree of tracheal stenosis remained always within the safe limit (less than 2.0) in all animals.
CONCLUSION
In a canine model of tracheal stenosis induced using Nd-YAG laser, the usefulness and safety of Natural Stent were similar to those of Dumon Stent. A clinical trial is necessary to document the usefulness and safety of Natural Stent in patients with tracheal stenosis.

Keyword

Animal; Airway; Bronchoscopy

MeSH Terms

Animals
Bronchoscopy
Dogs
Humans
Lasers, Solid-State
Stents*
Trachea
Tracheal Stenosis*