Tuberc Respir Dis.  2003 Mar;54(3):346-352. 10.4046/trd.2003.54.3.346.

Recurrent Respiratory Papillomatosis improved by Treatment with Interferon-alpha

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea. yskimdr@yahoo.co.kr
  • 2Department of Otolaryngology, College of Medicine, Pusan National University, Busan, Korea.

Abstract

Recurrent respiratory papillomatosis(RRP) is a chronic disease that is caused by the human papillomavirus(HPV) type 6 and 11. The most common site of the lesions is the larynx, but papillomas can occur throughout the respiratory and upper gastrointestinal tracts. Frequent recurrence of disease, can result in airway compromise and even death when papillomas either obstruct the airway or spread to the lung parenchyma. We encountered a case of a recurrent respiratory papillomatosis in a 23-year-old patient, who improved after treatment with interferon-alpha. The patiented with hoarseness, exertional dyspnea, and a productive cough. We report this case with a brief review of the relevant literature.

Keyword

Papillomatosis; HPV; Interferon-alpha

MeSH Terms

Chronic Disease
Cough
Dyspnea
Hoarseness
Humans
Interferon-alpha*
Larynx
Lung
Papilloma*
Recurrence
Upper Gastrointestinal Tract
Young Adult
Interferon-alpha
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