Tuberc Respir Dis.  2006 Nov;61(5):490-495. 10.4046/trd.2006.61.5.490.

Primary Endobronchial Leiomyoma Combined with Uterine Leiomyoma

• Shim HJ
• Lim JH
• Lee S
• Kim DH
• Park KJ
• Lee SR
• Jeong JP
• Son JG
• Kim SO
• Oh IJ
• Kim KS
• Kim YI
• Lim SC
• Kim YC
• Kim SM
• Na KJ

• KMID: 1970256
• DOI: http://doi.org/10.4046/trd.2006.61.5.490

Abstract

Leiomyoma of the bronchus is a very rare benign tumor of the lung. Most endobronchial leiomyomas occur as secondary foci of primary uterine leiomyoma. We herein report a case with endobronchial tumor that had a different pathology from a primary resected uterine leiomyoma and was therefor considered a primary endobronchial leiomyoma. A 51-year-old woman with a history of uterine myoma presented with productive cough and fever. Bronchoscopy revealed a lightly yellow colored mass lesion that totally obstructed the orifice of the left lower lobe of the lung. The diagnosis of leiomyoma was made by histological examination of the obtained specimen. We considered the possibility of a benign metastasizing pulmonary leiomyoma. For treatment and differential diagnosis, a left lower lobe lobectomy of the lung and total hysterectomy with bilateral salphingooopherectomy were performed. The differences between lung and uterine lesions were confirmed by morphologic finding and immunohistochemical staining. The pathological diagnosis was primary endobronchial leiomyoma combined with uterine myoma.

Keyword

Primary endobronchial leiomyoma; Uterine leiomyoma

MeSH Terms

Bronchi
Bronchoscopy
Cough
Diagnosis
Diagnosis, Differential
Female
Fever
Humans
Hysterectomy
Leiomyoma*
Lung
Middle Aged
Pathology

Figure

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  Figure 1 Chest radiography showed mass like lesion with passive atelectasis in left lower lobe.

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  Figure 2 Chest CT scan reveals about 4.8×3.8 cm sized enhancing mass in left lower lobe.

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  Figure 3 Bronchoscopy showed yellowish, round, hard mass, completely obstructing left lower lobe bronchus.

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  Figure 4 (A) Microscopic finding of the resected pulmonary mass showed interlacing bundles of spindle cells with eosihophilic cytoplasm and large vesicular nuclei(H&E, ×100). (B) The tumor cells show negative immunoreactivity for progesterone receptor on the nucleus(immunohistochemical stain,×200).

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  Figure 5 (A) The uterine mass showed higher celluar smooth muscle cells with multiply fascicular arragement(H&E,×100). (B) The tumor cells show positive immunoreactivity for progesterone receptor on the nucleus(immunohistochemical stain, ×200).

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