Tuberc Respir Dis.  2007 Apr;62(4):284-289. 10.4046/trd.2007.62.4.284.

Clinical Features of Patients with Lung Cancer and Upper Aerodigestive Tract Cancer

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ahnswine@naver.com
  • 2THuman Barrier Research Center, Yonsei University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND: To define the clinical features of patients with lung and upper aerodigestive tract cancer through a review of the histopathology, clinical features and follow-up results.
METHODS
Patients with lung and upper aerodigestive tract cancer who were diagnosed in Young dong Severance Hospital from 1992 to 2005, were retrospectively reviewed. The clinical data, radiologic findings, pathologic findings, treatment modalities were evaluated. Result: There was a total of 20 patients with aerodigestive tract cancer who were diagnosed with lung cancer over a 13 years period. The mean age was 58.45 +/-15.09 years and 19 cases were male. There were 14 smokers with an average pack year of 46 years. Twelve patients had aerodigestive tract cancer and later developed lung cancer, and 5 lung cancer patients were later diagnosed with aerodigestive tract cancer.
CONCLUSION
These results suggest that cancers of the aerodigestive tract and lung can arise as either dependent or independent events and most aerodigestive tract cancer patients who developed lung cancer are not treated properly. Therefore, regular low dose chest CT with close suspicion is needed to properly manage upper aerodigestive tract cancer patients.

Keyword

Aerodigestive tract cancer; Lung cancer; Clinical feature

MeSH Terms

Follow-Up Studies
Humans
Lung Neoplasms*
Lung*
Male
Retrospective Studies
Tomography, X-Ray Computed

Reference

1. X wu YH, Lippman SM, editors. Upper aerodigestive tract cancers. 1999. Philadelphia: Lippincott Williams & Wilkins.
2. Schwager K, Nebel A, Baier G, Hoppe F. [Second primary carcinomas in the upper aerodigestive tract in different locations and age groups]. Laryngorhinootologie. 2000. 79:599–603.
3. Gao X, Fisher SG, Mohideen N, Emami B. Second primary cancers in patients with laryngeal cancer: a population-based study. Int J Radiat Oncol Biol Phys. 2003. 56:427–435.
4. Vokes EE, Weichselbaum RR, Lippman SM, Hong WK. Head and neck cancer. N Engl J Med. 1993. 328:184–194.
5. Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer. 1953. 6:963–968.
6. Strong MS, Incze J, Vaughan CW. Field cancerization in the aerodigestive tract--its etiology, manifestation, and significance. J Otolaryngol. 1984. 13:1–6.
7. Hemminki K, Boffetta P. Multiple primary cancers as clues to environmental and heritable causes of cancer and mechanisms of carcinogenesis. IARC Sci Publ. 2004. (157):289–297.
8. Spitz MR, Hoque A, Trizna Z, Schantz SP, Amos CI, King TM, et al. Mutagen sensitivity as a risk factor for second malignant tumors following malignancies of the upper aerodigestive tract. J Natl Cancer Inst. 1994. 86:1681–1684.
9. Ha PK, Califano JA. The molecular biology of mucosal field cancerization of the head and neck. Crit Rev Oral Biol Med. 2003. 14:363–369.
10. Ministry of Health Welfare. 2005 Annual report of the Korea Central Cancer Registry. 2005. Gwacheon: Ministry of Health Welfare Republic of Korea.
11. Marioni G, Marchese-Ragona R, Cartei G, Marchese F, Staffieri A. Current opinion in diagnosis and treatment of laryngeal carcinoma. Cancer Treat Rev. 2006. 32:504–515.
12. Chan AT, Teo PM, Johnson PJ. Nasopharyngeal carcinoma. Ann Oncol. 2002. 13:1007–1015.
13. Dhooge IJ, De Vos M, Van Cauwenberge PB. Multiple primary malignant tumors in patients with head and neck cancer: results of a prospective study and future perspectives. Laryngoscope. 1998. 108:250–256.
14. Geurts TW, Nederlof PM, van den Brekel MW, van't Veer LJ, de Jong D, Hart AA, et al. Pulmonary squamous cell carcinoma following head and neck squamous cell carcinoma: metastasis or second primary? Clin Cancer Res. 2005. 11:6608–6614.
15. Ogden GR. Second malignant tumours in head and neck cancer. BMJ. 1991. 302:193–194.
16. Muir C, Weiland L. Upper aerodigestive tract cancers. Cancer. 1995. 75:S147–S153.
17. Lippman SM, Hong WK. Second malignant tumors in head and neck squamous cell carcinoma: the overshadowing threat for patients with early-stage disease. Int J Radiat Oncol Biol Phys. 1989. 17:691–694.
18. Carey TE. Field cancerization: are multiple primary cancers monoclonal or polyclonal? Ann Med. 1996. 28:183–188.
19. Chung KY, Mukhopadhyay T, Kim J, Casson A, Ro JY, Goepfert H, et al. Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract. Cancer Res. 1993. 53:1676–1683.
20. Bedi GC, Westra WH, Gabrielson E, Koch W, Sidransky D. Multiple head and neck tumors: evidence for a common clonal origin. Cancer Res. 1996. 56:2484–2487.
21. Califano J, van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S, et al. Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res. 1996. 56:2488–2492.
22. Califano J, Westra WH, Meininger G, Corio R, Koch WM, Sidransky D. Genetic progression and clonal relationship of recurrent premalignant head and neck lesions. Clin Cancer Res. 2000. 6:347–352.
23. Engelen AM, Stalpers LJ, Manni JJ, Ruijs JH, van Daal WA. Yearly chest radiography in the early detection of lung cancer following laryngeal cancer. Eur Arch Otorhinolaryngol. 1992. 249:364–369.
24. Fontana RS, Sanderson DR, Taylor WF, Woolner LB, Miller WE, Muhm JR, et al. Early lung cancer detection: results of the initial (prevalence) radiologic and cytologic screening in the Mayo Clinic study. Am Rev Respir Dis. 1984. 130:561–565.
25. Rachmat L, Vreeburg GC, de Vries N, Hordijk GJ, Lubsen H, Manni JJ, et al. The value of twice yearly bronchoscopy in the work-up and follow-up of patients with laryngeal cancer. Eur J Cancer. 1993. 29A:1096–1099.
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