J Cerebrovasc Endovasc Neurosurg.  2014 Sep;16(3):159-165. 10.7461/jcen.2014.16.3.159.

Relationship Between Systemic Thrombogenic or Thrombolytic Indices and Acute Increase of Spontaneous Intracerebral Hemorrhage

• Cho TG
• Lee JC
• Park SW
• Chung C
• Nam TK
• Hwang SN

• KMID: 1963152
• DOI: http://doi.org/10.7461/jcen.2014.16.3.159

Abstract

OBJECTIVE
The objective of this study was to determine the correlations between changes in thrombogenesis or thrombolysis related factors, and the acute increase of a spontaneous intracerebral hemorrhage (sICH).
MATERIALS AND METHODS
From January 2009 to October 2011, 225 patients with sICH were admitted to our hospital within 24 hours of onset. Among them, 111 patients with hypertensive sICH were enrolled in this study. Thrombogenic or thrombolytic factors were checked at admission. The authors checked computed tomography (CT) scans at admission and followed up the next day (between 12-24 hours) or at any time when neurologic signs were aggravated. Cases in which the hematoma was enlarged more than 33% were defined as Group A and the others were defined as Group B.
RESULTS
Group A included 30 patients (27%) and group B included 81 patients (73%). Factors including activated partial thromboplastin time, prothrombin time, fibrinogen, and D-dimer showed a greater increase in group A than in group B. Factors including antithrombin III, factor V, and factor X showed a greater increase in group A than in group B.
CONCLUSION
Based on the results of this study, it seems that the risk of increase in hematoma size can be predicted by serum thrombogenic or thrombolytic factors at admission.

Keyword

Intracerebral hemorrhage; Spontaneous; Correlation; Thrombogen; Thrombolysis

MeSH Terms

Antithrombin III
Cerebral Hemorrhage*
Factor V
Factor X
Fibrinogen
Hematoma
Humans
Neurologic Manifestations
Partial Thromboplastin Time
Prothrombin Time
Antithrombin III
Factor V
Factor X
Fibrinogen

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