Korean J Gastrointest Endosc.
2007 Oct;35(4):254-257.
A Case of Duodenal GIST Accompanied with Neurofibromatosis-1, Presenting with Gastrointestinal Bleeding
- Affiliations
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- 1Department of Internal Medicine and Digestive Disease Research Institute, WonKwang University College of Medicine, Iksan, Korea. medcsc@wmc.wonkwang.ac.kr
- 2Department of Pathology, WonKwang University College of Medicine, Iksan, Korea.
Abstract
- Gastrointestinal stroma tumors (GISTs) are CD117- positive primary mesenchymal tumors of the gastrointestinal tract and are noted to have a possible non-random association with neurofibromatosis-1 (NF-1, Von Recklinghausen disease). We report a case of a duodenal GIST presenting with gastrointestinal bleeding in a 74-year-old female, and this condition was accompanied with NF-1. A upper gastrointestinal endoscopy and abdominal computed tomography scan revealed several submucosal tumors in the duodenum, jejunum and ileum. Histological and immunohistochemical studies on the surgical resection specimen revealed gastrointestinal stromal tumors of an uncommitted type. The patient was treated with local excision of the tumors and is now in a favorable state.
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