Korean J Med.
2011 Dec;81(6):786-791.
Two Cases of Neuroendocrine Carcinoma and GIST in a Patient with Neurofibromatosis Type 1
- Affiliations
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- 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. drwookyun@jnu.ac.kr
- 2Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.
Abstract
- Patients with neurofibromatosis type 1 (NF1) are at increased risk of developing tumors throughout the gastrointestinal tract, including neuromas, gastrointestinal stromal tumors (GISTs), and periampullary somatostatin-rich carcinoids. The simultaneous occurrence of a GIST and a well-differentiated neuroendocrine carcinoma in a patient with NF1 is very rare. Here, we report two cases of the coexistence of a low-risk GIST in the jejunum with a well-differentiated neuroendocrine carcinoma in the duodenum in patients with NF1. These cases strengthen the known association of GIST with neuroendocrine carcinoma in patients with NF1.
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