J Korean Assoc Pediatr Surg.  2002 Jun;8(1):23-27.

Comparative Nerve Distribution of the Pylorus in Infantile Hypertrophic Pyloric Stenosis

• Kim GD
• Joo DH
• Yoo YO
• Park SH
• Park KH
• Park JB

Abstract

Infantile hypertrophic pyloric stenosis (IHPS) a common childhood disorders characterized by nonbilious projectile vomiting, an olive shaped mass in the right upper quadrant of the abdomen and visible gastric peristaltic wave in the upper abdomen. Its etiology and pathogenesis are not clear but abnormal nerve distribution of the pylorus has been postulated2-6. We performed immunocytochemical staning to the pyloric muscle from 10 IHPS and 3 controls patients, utilizing specific monoclonal antibody to NCAM(neural cell adhesion molecule). In IHPS patients, the number of NCAM protein immunoreactive nerve fibers were less than that in normal subjects. Auerbach myenteric plexuse was well developed and interbundle nerve plexuse was present but nerve fibers supplying individual muscle cells in smooth muscle bundles were poorly developed. These results indicate reduction of innervation in smooth muscles in IHPS patients that possibly contributes to the pathogenesis of IHPS.

Keyword

Infantile hypertrophic pyloric stenosis; Neural cell adhesion molecule; Nerve distribution

MeSH Terms

Abdomen
Cell Adhesion
Humans
Muscle Cells
Muscle, Smooth
Myenteric Plexus
Nerve Fibers
Neural Cell Adhesion Molecules
Olea
Pyloric Stenosis, Hypertrophic*
Pylorus*
Vomiting
Neural Cell Adhesion Molecules