J Korean Assoc Maxillofac Plast Reconstr Surg.  1998 May;20(2):158-165.

THE EffECT OF THE 5-FLUOROURACIL ON THE HAIR OF RAT: SCANNING ELECTRONMICROSCOPIC STUDY

• Choi YC
• Kim KW
• Lee JH

Abstract

This study was undertaken to observe the effects of the antineoplastic agent, 5-Fluorouracil(5 FU) on the hair in Sprague-Dawley white rats. Twenty four sprague-Dawley strain white rats, each weighing about 150-200 grams were used and divided into control and experimental groups. In the experimental group, eighteen rats were injected intraperitonially with 60 mg of 5-FU per killogram body weight with one time per two days. Six rats were injected with 0.5 cc of normal saline soultion intraperitoneally as a placebo on this control group. Rats were serially sacrificed on the first, third, fifth, seventh, tenth and fourteenth day after 2 times of injection of 5-FU and saline. The hair were obtained and observed SEM. After examination and comparision of all specimens, the results of this study were as follows : 1. In the control group, the scale and cuticle of hair was observed smooth surface and equal interval day, and irregular scale and cuticle of hair was observed smooth surface and equal interval 2. In the experimental group, the first day, scale change was seen from body of hair and crack was seen from fifth day, and irregular scale and cuticle of hair was seen from10, 14 days. 3. The apperance of root of hair was not almost change From above results, 5-Fluorouracil was more effective on the hair body. The change was begun from first day and crack of scale was seen from fifth day and irregular scale and cuticle of hair was seen from 10,14 days. The

MeSH Terms

Animals
Body Weight
Fluorouracil*
Hair*
Rats*
Rats, Sprague-Dawley
Fluorouracil