J Korean Androl Soc.  1995 Dec;13(2):95-101.

Relaxation Responses of Cavernous Smooth Muscles to Vasodilators in Impotent Patients with Hypercholesterolemia or Hypertriglyceridemia

• Kim SC
• Kim IK
• Lee MY
• Uhm DY

Abstract

To investigate the relaxation of cavernosal smooth muscles in impotent patients with hypercholesterolemia (hyper-C) or hypertriglyceridemia (Hypr-TG) in response to endothelium-dependent or endothelium-independent vasodilators, the erectile response to intracavernous injection of papaverine and the relaxation response of isolated cavernous smooth muscles were observed. The erectile response in the patients with hyper-C (n=13) or Hyper-TG (n=104) did not differ from that of the impotent men without abnormal lipid metabolism (control group; n=273). The relazation responses to acetylcholine, adenosine and bradykinin of tissue (n=5) from impotent patients with hyper-C were less pronounced than those of the tissue from the control group (n=15), but there was no significant difference between the two groups in the relaxation response to papaverine or verapamil. The cavernous tissue (n=6) from the impotent patients with hyper-TG showed no difference from the control tissues in the relaxation response to either the endothelium-dependent or endothelium-independent vasodilator. In conclusion, hyper-C is associated with impaired endothelium-dependent relaxation of cavernosal smooth muscle in man, whereas hyper-TG alone may not be associated with such impairment.

MeSH Terms

Acetylcholine
Adenosine
Bradykinin
Erectile Dysfunction
Humans
Hypercholesterolemia*
Hypertriglyceridemia*
Lipid Metabolism
Male
Muscle, Smooth*
Papaverine
Relaxation*
Vasodilator Agents*
Verapamil
Acetylcholine
Adenosine
Bradykinin
Papaverine
Vasodilator Agents
Verapamil