J Korean Neurol Assoc.
2006 Feb;24(1):31-37.
The Quantitative 18-fluorodeoxyglucose PET Study in the Differential Diagnosis between Idiopathic Parkinson's Disease and Multiple System Atrophy
- Affiliations
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- 1Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. mslee@yumc.yonsei.ac.kr
- 2Department of Radiology, Youngdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Abstract
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BACKGROUND: Overlapping clinical features of idiopathic Parkinson's disease (IPD) and multiple system atrophy (MSA) make it difficult to conduct an accurate differential diagnosis. We performed a quantitative F18- fluorodeoxyglucose PET (FDG PET) and measured the striatal and cerebellar glucose metabolism to evaluate the efficacy of a FDG PET study in the differential diagnosis between IPD and MSA.
METHODS
This study included 19 patients with IPD, 28 patients with MSA (MSA-P : MSA-C = 19 : 9) and 12 age matched normal controls. A FDG PET study was performed in all subjects and the original PET image was corrected with the radioactivity curve obtained by repetitive sampling of the radial arterial blood.
RESULTS
The measurements of striatal and cerebellar glucose metabolisms of the patients with MSA-P were significantly lower than those of the patients with IPD (P<0.001). However, the measurement of the caudate nucleus provided the most reliable clue for the differential diagnosis between IPD and MSA-P (sensitivity 94.7% and specificity 94.7%). In the patients with MSA-C, the glucose metabolism of the cerebellar vermis (P<0.001), cerebellar cortex (P<0.001) and putamen (P<0.05) was significantly lower than those of the patients with IPD.
CONCLUSIONS
Quantitative FDG PET is a useful and reliable method in making a differential diagnosis between IPD and MSA.
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