J Korean Neurol Assoc.
2004 Jun;22(3):272-275.
Anti-Hu Antibody Associated Sensory Neuronopathy Accompanied by Autonomic Dysfunction
- Affiliations
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- 1Department of Neurology, Pusan National College of Medicine, University, Korea. dskim@pusan.ac.kr
- 2Department of Internal Medicine, Pusan National College of Medicine, University, Korea.
Abstract
- Paraneoplastic sensory neuronopathy may present with autonomic dysfunction resulting either from autonomic neuropathy, or invasion/compression by tumor. We present a 61-year-old female presented with frequent syncope, anhidrosis, and sensory change. Investigations disclosed sensory-autonomic polyneuropathy with positive anti-Hu antibody. The chest computed tomography showed a left mediastinal mass with invasion to the brachiocephalic vein, and a small cell lung cancer was confirmed. She was treated with radiation therapy showing limited improvement. The possible causes of autonomic dysfunction in our patient were discussed.
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