J Korean Ophthalmol Soc.  1997 Jul;38(7):1179-1187.

Proliferative Effect of Retinal Glial Cells by Growth Factors

• Cho NC
• Lee MC
• Han HJ
• Ahn BG

Abstract

The authors tried to evaluate the effect of the growth factors on cell proliferation in the human retina astrocyte culture. Each growth factor, EGF, bFGF, GGF, IGF-1 or PDGF, together with BrdU was added to astrocytes-enriched cultures in the serum-free media. The proliferating effect of each growth factor was evaluated by a double immunofluo- rescenece labelling for GFAP and BrdU. By and addition of each growth factor, the number of retinal astrocytes at the synthetic stage significantly increased than those of control group (p<0.01). In comparision, PDGF was more potent than IGF-1 (p<0.01). Above data extended the concept of astrocytic proliferation caused by several growth factors in human retinal injury.

Keyword

Growth Factor; Astrocyte; Retinal Injury

MeSH Terms

Astrocytes
Bromodeoxyuridine
Cell Proliferation
Culture Media, Serum-Free
Epidermal Growth Factor
Humans
Insulin-Like Growth Factor I
Intercellular Signaling Peptides and Proteins*
Neuroglia*
Retina
Retinaldehyde*
Bromodeoxyuridine
Culture Media, Serum-Free
Epidermal Growth Factor
Insulin-Like Growth Factor I
Intercellular Signaling Peptides and Proteins
Retinaldehyde