J Korean Ophthalmol Soc.  1992 Sep;33(9):844-852.

The Effect of Intravitreal Endotoxin Injection on Vitreoretinal Membrane Formation

• Kim WJ
• Chung H

Abstract

The course of experimental uveitis and inflammatory membrane proliferation was observed following intravitreal single injection of bacterial endotoxins (Escherichia coli, Salmonella typhimurium, Shigella flexneri). 30 microgram/O.1cc of one endotoxin was injected to 5 pigmented rabbits (total 15 rabbits), then the inflammatory processes of anterior chamber and vitreous cavity were evaluated and the histologic review was also made. Remarkable inflammatory signs were observed in 24-48 hours post-injection, decreased gradually, and disappeared in 1 week post-injection finally. The proliferation of vitreoretinal membrane was observed as early as in 2 weeks post-injection. In histologic examination, there were vitreal thickening, strand-like fibrous structure, and infiltration of spindle shaped cells and monocular cells in 2 weeks post-injection. The membrane, arising from the disc, was composed of the large vascular stalk, fibrous bundles, spindle shaped fibroblast-like cells, and round cells. In this results, the pathogenesis of intraocular membrane proliferation following intraocular inflammation could be understood more precisely.

Keyword

Endotoxin; Experimental uveitis; Histologic examination; Inflammatory membrane proliferation

MeSH Terms

Anterior Chamber
Endotoxins
Inflammation
Membranes*
Rabbits
Salmonella typhimurium
Shigella
Uveitis
Endotoxins