J Korean Ophthalmol Soc.  1964 Nov;5(2):47-53.

The Effect of Chlordiazepoxide (Olympia) on Central Serous Retinopathy

• Sohn MS
• Choi CS

Abstract

Central serous retinopathies were arbitrarily divided into two groups; one mainly with edema of the macula and the other with discoloration opacity and a number of tiny yellow spots in and around the macula. Eight cases of central serous retinopathy with macular edema were selected to have oral administration of chlordiazepoxide, 20mg to 60mg a day. Of eight cases of the variety, six cases showed a marked improvement of visual acuity and a complete subsidence of macular edema within ten days after the administration of the drug. Two other cases were also benefitted by the regime. The drug was found to be equally effective even in the patients who had been on the other treatments for varying lengths of time without success. The mode of action of the drug is not yet fully understood. It is, however, assumed that the effectiveness of the drug on the disease might be due to relief of the stress which, in turn, leads to the relaxation of spasm of the retinal and or choroidal arterioles in the vicinity of the macula.

MeSH Terms

Administration, Oral
Arterioles
Central Serous Chorioretinopathy*
Chlordiazepoxide*
Choroid
Edema
Humans
Macular Edema
Relaxation
Retinaldehyde
Spasm
Visual Acuity
Chlordiazepoxide
Retinaldehyde