J Korean Radiol Soc.
2007 Mar;56(3):225-232. 10.3348/jkrs.2007.56.3.225.
Efficacy of a Paclitaxel-Eluting Nitinol Stent on the Inhibition of Pseudointimal Hyperplasia in a Transjugular Intrahepatic Portosystemic Shunt: An Experimental Study in a Swine Model
- Affiliations
-
- 1Department of Diagnostic Radiology, Kyung Hee University Hospital, Seoul, Korea. ohjh6108@hanmail.net
- 2Department of Radiology, Korea University Guro Hospital, Seoul, Korea.
- 3Department of Pathology, Kyung Hee University Hospital, Seoul, Korea.
- 4Department of Radiology, University of Ulsan, College of Medicine, Seoul, Korea.
- 5Department of Polymer Science and Engineering, Hannam University, Taejon, Korea.
- KMID: 1945380
- DOI: http://doi.org/10.3348/jkrs.2007.56.3.225
Abstract
-
PURPOSE: To evaluate the efficacy of a paclitaxel-eluting nitinol stent on the inhibition of pseudointimal hyperplasia in a transjugular intrahepatic portosystemic shunt.
MATERIALS AND METHODS
Twelve pigs were used in this study. Two types of 10-mm diameter and 60-mm long nitinol stents were made for a transjugular intrahepatic portosystemic shunt by coating them with a polyurethane solution, with and without paclitaxel. Each transjugular intrahepatic portosystemic shunt was created successfully in the 12 swine with 7 paclitaxel-eluting stents and 5 polyurethane stents. Five swine in each group were followed-up for 14 days due to the death of 2 swine given the paclitaxel-eluting stents. The proliferation of the pseudointima was evaluated on both follow-up portograms and histopathology examinations. The mean maximum pseudointimal hyperplasia is expressed as the percentage of the stent radius.
RESULTS
On the portograms, all the transjugular intrahepatic portosystemic shunts using the paclitaxel-eluting stents maintained patency despite there being a complete occlusion of the polyurethane stents in all the animals. The histopathology analysis revealed the mean maximum pseudointimal hyperplasia to be 25% and 76% in the paclitaxel-eluting and control stents, respectively.
CONCLUSION
A transjugular intrahepatic portosystemic shunt with a paclitaxel-eluting nitinol stent appears to significantly inhibit the formation of pseudointimal hyperplasia.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Efficacy of a Dexamethasone-Eluting Nitinol Stent on the Inhibition of Pseudointimal Hyperplasia in a Transjugular Intrahepatic Portosystemic Shunt: An Experimental Study in a Swine Model
- Percutaneous retrieval of a misplaced transjugular intrahepatic portosystemic shunt stent using the rigid endobronchial forceps
- A new and improved transjugular intrahepatic portosystemic shunt (TIPS) stent graft: Controlled expansion
- Recanalization of an Occluded Intrahepatic Portosystemic Covered Stent via the Percutaneous Transhepatic Approach
- Effects of Intraluminal Irradiation with Holmium-166 for TIPS Stenosis: Experimental Study in a Swine Model
