J Korean Rheum Assoc.  1994 Jan;1(1):91-97.

Systemic Lupus Erythematosus With Involvement Of Liver And Central Nervous System: A Case Report

• Lee SC
• Lee SK
• Hong CS
• Park CI

Abstract

We report a pateint with CNS-SLE who initially manifested liver involvement. We emphasize the difficulty in differentiating autoimmune hepatitis and hepatic involvement of SLE, clinically, immunologically, radiologically, pathologically. Neuropsychiatric disorders casued by lupus activity occur during the course of the illness in 35~75% of patients with SLE. It is a poor prognostic sign and frequent cause of death in lupus patients. Recently some evidence suggest that single-photon-emission computed tomography(SPECT) of brain is useful for detecting abnormalities of regional cerebral blood flow in patients with CNS lupus. We were able to conclude that CNS symptoms in this patient were due to CNS involovement of SLE. Although MRI of brain showed some high signal intensity in parenchyme of brain, this findings were said to be common in chronic liver diseases. In this situdation we think that SPECT of brain might be performed for differentiation of the cause of CNS symptoms in SLE patient with chronic liver disease.

Keyword

systemic lupus erythematosus; lupoid hepatitis; CNS-SLE; SPECT

MeSH Terms

Brain
Cause of Death
Central Nervous System*
Hepatitis, Autoimmune
Humans
Liver Diseases
Liver*
Lupus Erythematosus, Systemic*
Magnetic Resonance Imaging
Tomography, Emission-Computed, Single-Photon