Korean J Anesthesiol.  2007 Nov;53(5):609-614. 10.4097/kjae.2007.53.5.609.

The Effect of Fentanyl and Remifentanil on the Side Effects after Sevoflurane Anesthesia in Children Undergoing Herniorrhaphy

• Cho HY
• Kim CH
• Han JI
• Kim DY

• KMID: 1937375
• DOI: http://doi.org/10.4097/kjae.2007.53.5.609

Abstract

BACKGROUND: Emergence agitation is one of the major problems in pediatric anesthesia. The aim of this study was to compare the effect of remifentanil and fentanyl on the incidence of emergence agitation, postoperative pain and postoperative vomiting after administering anesthesia with sevoflurane.
METHODS
Thirty ASA physical status 1-2 children, aged 12-60 months undergoing a unilateral inguinal herniorrhaphy were randomized to receive either remifentanil (group R, bolus 0.5microgram/kg; infusion 0.2microgram/kg/min) or fentanyl (group F, 1microgram/kg) after thiopental sodium induction. All patients received sevoflurane for maintenance of anesthesia. Heart rate and blood pressure were measured at baseline (T0), preintubation (T1), postintubation (T2) and 5 minutes after intubation (T3). The agitation score, pain score and incidence of postoperative vomiting were assessed upon arrival at the recovery room (P0), 30 minutes thereafter (P1) and 3 hours after discharge from the recovery room (P2).
RESULTS
The agitation score were higher in group R at P0 (P < 0.05). The pain score was higher in group R at P0, P1 and P2 (P < 0.05). Postoperative vomiting was present only in one patient in group F.
CONCLUSIONS
Adjuvant use of fentanyl during sevoflurane anesthesia revealed advantages over the use of remifentanil concerning the incidence of postoperative agitation and pain without any prolongation of recovery time.

Keyword

fentanyl; herniorrhaphy; remifentanil; sevoflurane

MeSH Terms

Anesthesia*
Blood Pressure
Child*
Dihydroergotamine
Fentanyl*
Heart Rate
Herniorrhaphy*
Humans
Incidence
Intubation
Pain, Postoperative
Postoperative Nausea and Vomiting
Recovery Room
Thiopental
Dihydroergotamine
Fentanyl
Thiopental