Korean J Anesthesiol.  2005 Oct;49(4):455-460. 10.4097/kjae.2005.49.4.455.

The Heart Rate Response to Intravenous Atropine during Propofol or Enflurane Anesthesia

• Jung SS
• Kim JS
• Kim KS
• Shin OY
• Kang WJ

• KMID: 1936843
• DOI: http://doi.org/10.4097/kjae.2005.49.4.455

Abstract

BACKGROUND: Propofol increases the risk of bradycardia compared with other anesthetics. This paper reports the heart rate response to intravenous atropine during propofol and enflurane anesthesia.
METHODS
Sixty patients undergoing a transabdominal hysterectomy under general anesthesia were randomly assigned to two groups: the propofol group and the enflurane group. All the patients received midazolam 2 mg intramuscularly and were then anesthetized with propofol or enflurane. The blood pressure and heart rate were taken at 1 min intervals for 10 min after a bolus injection of atropine 5microgram/kg.
RESULTS
In the enflurane group, the systolic blood pressure and heart rate were increased significantly at 1, 2 and 3 min after the atropine injection (P<0.05). When the two groups were compared, the heart rate in the enflurane group was significantly higher at 1, 2 and 3 min after atropine injection than in the propofol group (P<0.05).
CONCLUSIONS
The heart rate response to intravenous atropine during propofol anesthesia is attenuated compared with enflurane anesthesia.

Keyword

atropine; bradycardia; enflurane; heart rate; propofol

MeSH Terms

Anesthesia*
Anesthesia, General
Anesthetics
Atropine*
Blood Pressure
Bradycardia
Enflurane*
Heart Rate*
Heart*
Humans
Hysterectomy
Midazolam
Propofol*
Anesthetics
Atropine
Enflurane
Midazolam
Propofol