Korean J Anesthesiol.  2006 Aug;51(2):261-266. 10.4097/kjae.2006.51.2.261.

Neuroleptic Malignant Syndrome Caused by Risperidone Overdose: A case report

• Kim JB
• Im KS
• Lee JM
• Jung HJ
• Kim DY
• Hong SH

• KMID: 1936673
• DOI: http://doi.org/10.4097/kjae.2006.51.2.261

Abstract

Neuroleptic malignant syndrome (NMS) is a rare, but potentially fatal idiosyncratic reaction to neuroleptics characterized by muscle rigidity, fever, altered consciousness, autonomic instability, leukocytosis and elevated creatinine phosphokinase level suggesting muscle injury. The incidence of NMS is estimated to be between 0.07 and 2.2% among patients receiving neuroleptics, with a motality of 11%. Although the pathophysiology of NMS is not completely understood, reduced dopaminergic activity secondary to antipsychotic induced dopamine receptor blockage is considered to be the best explanation to date. We experienced NMS in a 22-year-old male with antipsychotic drug intoxication who underwent primary closure of dual, self-inflicted wrist laceration. We recognized as NMS about 30 minutes after induction of general anesthesia. All anesthetics were stopped, and supportive care was performed with management of hyperthermia and fluid. Also, Dantrolene sodium and bromocriptine were administered. The patient recovered without any complication.

Keyword

neuroleptic malignant syndrome (NMS)

MeSH Terms

Anesthesia, General
Anesthetics
Antipsychotic Agents
Bromocriptine
Consciousness
Creatinine
Dantrolene
Fever
Humans
Incidence
Lacerations
Leukocytosis
Male
Muscle Rigidity
Neuroleptic Malignant Syndrome*
Receptors, Dopamine
Risperidone*
Wrist
Young Adult
Anesthetics
Antipsychotic Agents
Bromocriptine
Creatinine
Dantrolene
Receptors, Dopamine
Risperidone