Korean J Anesthesiol.  2006 Aug;51(2):190-194. 10.4097/kjae.2006.51.2.190.

The Analgesic Effects of Dose of Butorphanol Administered in Intravenous Patient Controlled Analgesia after Subtotal Gastrectomy

• Kim ST
• Kim KH
• Kim SH
• Chang TH
• Ryu SJ
• Kim DS

• KMID: 1936659
• DOI: http://doi.org/10.4097/kjae.2006.51.2.190

Abstract

BACKGROUND: Butorphanol, a synthetic partial agonist-antagonist narcotic, produces adequate analgesia for postoperative pain. This study was designed to determine the appropriate dosage of butorphanol when administered with ketorolac by intravenous patient controlled analgesia (IV-PCA) after subtotal gastrectomy.
METHODS
Ninety ASA physical status I or II patients undergoing subtotal gastrectomy were randomly allocated into one of three groups according to type of drug used (n = 30 for each group). The patients were divided into group B6 (butorphanol 6 mg), group B10 (butorphanol 10 mg) and group B14 (butorphanol 14 mg). Drugs for each group were mixed with 300 mg of ketorolac and normal saline (total amount: 100 ml) for infusion. Bolus dose, maintenance dose and lockout interval were 0.5 ml per each press, 1 ml/hr and 15 minutes, respectively. In each group, numerical rating scale (NRS) score, sedation score and incidence of side effect were checked.
RESULTS
There were no significant differences in analgesic effects and sedation score among three groups but the NRS score of group B14 is lower than that of group B6 (P < 0.05) 3 hrs after the recovery room.
CONCLUSIONS
We recommend 6 mg butorphanol, mixed with 300 mg of ketorolac, and normal saline for postoperative pain relief using IV-PCA.

Keyword

analgesia; butorphanol; intravenous patient controlled analgesia; pain

MeSH Terms

Analgesia
Analgesia, Patient-Controlled*
Butorphanol*
Gastrectomy*
Humans
Incidence
Ketorolac
Pain, Postoperative
Recovery Room
Butorphanol
Ketorolac