Korean J Anesthesiol.  2003 Nov;45(5):601-605. 10.4097/kjae.2003.45.5.601.

Effect of Acute Normovolemic Hemodilution on Homologous Blood Saving during Off-Pump CABG

• Choi SR
• Kim JY
• Chin YJ

• KMID: 1935948
• DOI: http://doi.org/10.4097/kjae.2003.45.5.601

Abstract

BACKGROUND: Acute normovolemic hemodilution (ANH) is accepted to be the easiest and most economical method of autotransfusion. This study was performed to investigate the clinical usefulness of ANH in patients undergoing off-pump CABG.
METHODS
Thirty patients were randomly divided into two groups. In the ANH group, 753.3 +/- 51.6 ml of fresh autologous whole blood were sequestrated from a pulmonary artery catheter following induction of anesthesia with simultaneous infusion of colloids and crystalloid solution from a separate line. Perioperative changes of hemoglobin, hematocrit level, platelet counts, prothrombin time, cardiac output, transfusion requirement and the amount of postoperative drainage were compared between the two groups.
RESULTS
Perioperative changes of platelet counts and PT showed no significant differences between the two groups. Less allogenic blood was used in the ANH group (0.27 +/- 0.46 unit) than in the control group (1.27 +/- 0.80 unit) in the operation room.
CONCLUSIONS
ANH can decrease the transfusion requirement in off-pump CABG.

Keyword

acute normovolemic hemodilution; allogenic transfusion; autotransfusion; coronary artery bypass graft

MeSH Terms

Anesthesia
Blood Transfusion, Autologous
Cardiac Output
Catheters
Colloids
Drainage
Hematocrit
Hemodilution*
Humans
Platelet Count
Prothrombin Time
Pulmonary Artery
Colloids