Korean J Anesthesiol.  1991 Dec;24(6):1147-1153. 10.4097/kjae.1991.24.6.1147.

Cardiovascular Effects of Acute Isovolemic Hemodilution

• Lee KH
• Lim YJ
• Yum KW

• KMID: 2237064
• DOI: http://doi.org/10.4097/kjae.1991.24.6.1147

Abstract

Acute normovolemic hemodilution is widely used to conserve blood and to minimize the need for homologous blood transfusion during operation. To evaluate the effects of aeute isovolemic hemodilution on hemodynamics and oxygen transport, pulmonary artery catheter and radial artery catheter were introduced in 8 patients in whom maxillofacial or Wertheim's operation were performed. Blood(estimated from allowable blood loss) was withdrawn from radial artery, and simultaneously replaced by intravenous administration of 5% plasmanate and Hartmann solution. Acute isovolemic hemodilution decreased the hematocrit level from 33.2+/-3.7% to 29.6+/-2.9%. Cardiac output increased significantly, which was associated with decreased systemic vaacular resistance. Oxygen transport and oxygen consumption increased despite a decrease in oxygen carrying capacity. Heart rate, mean arterial perssure, mean pulmonary arterial pressure, central venous pressure, and pulmonary capillary wedge pressure did not change significantly during hemodilution. The results indicate that blood perfusion and oxygenation to tissue were well maintained in the hemodilution of the magnitude used in this study. Therfore it could be concluded that acute isovolemic hemodilution is a safe and relatively simple method of conserving blood and minimizing homologous blood transfusion.

Keyword

Acute isovolemic hemodilution; Cardiac output; Oxygen transport

MeSH Terms

Administration, Intravenous
Arterial Pressure
Blood Transfusion
Cardiac Output
Catheters
Central Venous Pressure
Natural Resources
Heart Rate
Hematocrit
Hemodilution*
Hemodynamics
Humans
Oxygen
Oxygen Consumption
Perfusion
Pulmonary Artery
Pulmonary Wedge Pressure
Radial Artery
Oxygen