Korean J Anesthesiol.  1995 Apr;28(4):502-507. 10.4097/kjae.1995.28.4.502.

The effect of diltiazem on intrapulmonary shunt in dog under sevoflurane anesthesia

• Kim CS
• Cheong IY

• KMID: 1934332
• DOI: http://doi.org/10.4097/kjae.1995.28.4.502

Abstract

The effects of sevoflurane and subsequent administration of diltiazem on intrapulmonary shunt and oxygenation were studied in pentobarbital anesthetized dogs. After inhalation of 1MAC of sevoflurane and subsequent intravenous administration of clinical dose of diltiazem (loading dose 0.2 mg/kg, maintenance dose 0.01 mg/kg/min), there were no changes in cardiac output, arterial oxygen tension, mixed venous oxygen tension, oxygen transport, oxygen consumption, intrapul-monary shunt ratio, pulmonary vascular resistance, alveolar-arterial oxygen difference. After intravenous administration of diltiazem with bolus (0.4 mg/kg) and maintenance dose (0.02 mg/ kg/min), pulmonary vascular resistance was significantly decreased (p<0.05) but the other parameters indicating pulmonaruy hemodynamics and oxygenation were unchanged. These results suggest that concomittent use of the two classes of drugs is not induce significant changes in pulmonary hemodynamic and oxygenation, and can be used safely in patient with normal cardiopulmonary function when clinical concentration of both were used.

Keyword

Anesthetics; volatile; sevoflurane; calcium channel blocker; diltiazem; oxygenation

MeSH Terms

Administration, Intravenous
Anesthesia*
Anesthetics
Animals
Cardiac Output
Diltiazem*
Dogs*
Hemodynamics
Humans
Inhalation
Oxygen
Oxygen Consumption
Pentobarbital
Vascular Resistance
Anesthetics
Diltiazem
Oxygen
Pentobarbital