Korean J Anesthesiol.  1992 Dec;25(6):1073-1077. 10.4097/kjae.1992.25.6.1073.

Effect of Midazolam , Droperidol and Clonidine on Dysrhythmia and Hypertension Caused by Intracerebroventricular Bupivacaine in Cats

• Han SM

• KMID: 1934095
• DOI: http://doi.org/10.4097/kjae.1992.25.6.1073

Abstract

Intracerebroventricular(ICV) bupivacaine produces dysrhythmias and hypertension by altering autonomic nervous system outflow from the CNS. Author evaluated the effect of ICV infusion of saline(0.15 ml), midazolam(0.75 mg), droperidol(0.375 mg), and clondine(0.0225 mg) on dysrhythmia and hypertension induced by ICV bupivacaine in 20 cats. After ICV infusion of bupivacaine, all cats in 4 groups(5 cats in each) developed dysrhythmia and hypertension. Dysrhythmia disappeared within 5 minutes in midazolam, droperidol and clonidine group except saline group but recurred in two of the five cats in midazolam group. Mean arterial pressure decreased more significantly in droperidol and clonidine group than midazolam group<0.05), and heart rate decreased significantly in c1onidine group after ten minutes(p < 0.01). It is concluded that clonidine and droperidol are more potent and effective than midazolam on hypertension and dysrhythmia caused by ICV bupivacaine.

Keyword

Intracerebroventricle; Bupivacaine; Clonidine; Droperidol; Midazolam

MeSH Terms

Animals
Arterial Pressure
Autonomic Nervous System
Bupivacaine*
Cats*
Clonidine*
Droperidol*
Heart Rate
Hypertension*
Midazolam*
Bupivacaine
Clonidine
Droperidol
Midazolam