Korean J Anesthesiol.  1989 Oct;22(5):689-699. 10.4097/kjae.1989.22.5.689.

Effect of Methylpredisolone to the Changes of Blood Sugar Levels , Blood Pressure and Heart Rate During General Anesthesia

• Kim YH
• Lee GY
• Lee CH

• KMID: 1933785
• DOI: http://doi.org/10.4097/kjae.1989.22.5.689

Abstract

Maintenance of optimum blood sugar level is a basic factor in energy metabolism and maintenance of cell function. Insulin and glucagon are the important factors in blood sugar control. The surgical stress increases the secretion of catecholamine, glucocorticoid and induces hyperglycemia. These hormones inhibit glucose-induced insulin secretion. Inhalation anesthesia affect the carbohydrate metabolism by reducing glucose-induced insulinogenic response and inhibiting the insulin secretion from the pancreas. Diazepam and muscle relaxant used in balanced anesthesia do not significantly affect blood glucose level. Methylprednisolone has an important role in maintenance of homesostasis of body function and is often used in surgical anesthesia. When large dose of methylprednisolone is administered to a normal person, fasting blood increases and glucose tolerance decreases. These factors may aggravate the symptoms of diabetic patients. We measured blood sugar level, systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate after administration of methylprednisolone. The results were as follows: 1) Blood sugar leve increased significantly in all groups after induction of anesthesia, and the increase was greater in methylpredinsolone group and halothane anesthesia group. 2) Systolic blood pressure increased significantly and more in methylprednisolone group in balanced anesthesia. In halothane anesthesia group, systolic blood pressure decreased, but recovered in methylprednisolone group, 2 hours after anesthesia. 3) The changes in mean and diastolic blood pressure were similar to the changes in systolic blood pressure in all groups. 4) The changes in heart rate in methylprednisolone group was less than other groups.

Keyword

Methylprednisolone

MeSH Terms

Anesthesia
Anesthesia, General*
Anesthesia, Inhalation
Arterial Pressure
Balanced Anesthesia
Blood Glucose*
Blood Pressure*
Carbohydrate Metabolism
Diazepam
Energy Metabolism
Fasting
Glucagon
Glucose
Halothane
Heart Rate*
Heart*
Humans
Hyperglycemia
Insulin
Methylprednisolone
Pancreas
Blood Glucose
Diazepam
Glucagon
Glucose
Halothane
Insulin
Methylprednisolone