Korean J Anesthesiol.
1989 Dec;22(6):915-921. 10.4097/kjae.1989.22.6.915.
Changes of Blood Pressure and Heart Rate during Endotracheal Intubation with Lidocaine and Fentanyl Pretreatment
- Affiliations
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- 1Department of Anesthesiology, Kyungpook National University Hospital, Taegu, Korea.
- KMID: 1933763
- DOI: http://doi.org/10.4097/kjae.1989.22.6.915
Abstract
- The effects of lidocaine and fentanyl on controlling the hemodynamic responses to laryngoscopy and intubation have been compared in 39 adult normotensive patients undergoing elective thyroidectomy surgery. Three groups of 13 patients were observed. Patients were randomly assigned to receive thiopenta15 mg/kg alone (control group), lidocaine 1 mg/kg with thiopental 5 mg/kg (lidocaine group) or fentanyl 3 ug/kg with thiopental 5 mg/kg (fentanyl group) for induction of anesthesia. The changes of systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP), heart rate and ECG abnormalities were recorded every minute throughout and compared with preinduction control values. The results were as follows. Control and lidocaine groups showed significant increase of SBP, MAP and DBP (p<0.001, p<0.05) but no significant increases were noted in fentanyl group with tracheal intubation. Significant elevation of heart rate following intubation were observed in all group (p<0.001) and sustained for several minutes. Sinus tachycardia, premature ventricular contraction, bigeminy were observed in every group during induction but the incidences were low in the fentanyl group. It is suggested from the above results that intravenous injection of the lidocaine or fentanyl reduces the magnitude of blood pressure elevation following intubation effectively but heart rate, and cardiovascular respones are more stable with fentanyl than lidocaine.
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