Korean J Anesthesiol.  1986 Feb;19(1):8-13.

Studies on Bradycardia by Centrally Administered Atropine in the Rabbit

• Song HS

Abstract

The author observed the cahnges in the heart rate and blood pressure following injection of atropine and scopolamine into the lateral ventricle or cisterna magna of rabbits under urethane anesthesia. The results were as followings: 1. Intraventricular atropine(30, 100, 300ug) slightly decreased the heart rate, while the same amouts of scopolamine did not. 2) Atropine(30, 100, 300ug) administered into the cisterna magna produced a marked decrease in the heart rate, while the same amounts of scopolamine produced only a slight decrease. 3) The decrease in the heart rate by intracisternal atropine was less prominent in the vagotomized or methylatropinized rabbits. 4) After intracisternal injection of regitine, intracisternal norepinephrine did not produce a decrease in the heart rate, while intracisternal atropine produced a slight decrease. 4) After simultaneous administrations of intracisternal regitine and intravenous methylatropine, intracisternal stropine did not produce a decrease in heart rate. 6) The stimulation of the vagal center and central adrenoreceptors may be responsible for the bradycardia by central atropine. It is suggested that the bradycardia by atropine in man is not related to that in the present experiments.

MeSH Terms

Anesthesia
Atropine*
Blood Pressure
Bradycardia*
Cisterna Magna
Heart Rate
Lateral Ventricles
Norepinephrine
Phentolamine
Rabbits
Scopolamine Hydrobromide
Urethane
Atropine
Norepinephrine
Phentolamine
Scopolamine Hydrobromide
Urethane