Korean J Anesthesiol.  1988 Dec;21(6):910-913. 10.4097/kjae.1988.21.6.910.

Mechanical Ventilation with Superimposed High - Frequency Ventilation

• Kim JH
• Lee KM
• Kim WO
• Oh HK

• KMID: 1933073
• DOI: http://doi.org/10.4097/kjae.1988.21.6.910

Abstract

The efficacy of high frequency oscillation superimposed on conventional mechanical ventilation (combined ventilation) was evaluated in 11 patients requiring respiratory care. These patients were comatose and in an apneic state. The conventional ventilator was initially set at a tidal volume of 10ml/kg at a rate of 10/min.(control) and half of the tidal volume was delivered throughout superimposing high frequency oscillations. While changing high frequency rates(5,10 and 15 Hz) at an interval of 15 minutes(experimental groups 1,2 and 3), blood pressure, pulse rate, peak and mean airway pressure, and expiratory volume were measured and arterial blood gas analysis was performed. There were no significant differences in cardiovascular and blood gas parameters between each group and the control. But PaCO2 and PaO2 rose and airway pressures(peak and mean airway pressure) were reduced as the high frequency rates increased, especially in the group with the largest samplitude oscillations. These results suggest that combined ventilation can achieve an adequate gas exchange and low airway pressure without cardiovascular embarrassment in respiratory support. This should help to provide an alternative mode for the management of patients with respiratory failure requiring mechanical ventilation.

Keyword

Mechanical ventilation; Combined ventilation; High frequency ventilation

MeSH Terms

Blood Gas Analysis
Blood Pressure
Coma
Heart Rate
High-Frequency Ventilation
Humans
Respiration, Artificial*
Respiratory Insufficiency
Tidal Volume
Ventilation*
Ventilators, Mechanical