Korean J Gastrointest Endosc.
2004 Jan;28(1):25-28.
Esophageal Ulcer Induced by Alendronate
- Affiliations
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- 1Department of Gastroenterology, Kyung Hee University College of Medicine, Seoul, Korea. cywgi@chollian.net
Abstract
- Alendronate sodium (Fosamax(R)) is an aminophosphonate used in treatment of postmenopausal osteoporosis by inhibition of osteoclastic activity. Esophageal ulcers related to alendronate use have been reported at the rate of 2~6%. However, there have been no reports of esophagitis or esophageal ulcer by alendronate in Korea. We present a case of esophageal ulcer caused by alendronate. The patient presented with retrosternal pain and severe odynophagia for a few days. Esophagogastroduodenoscopy revealed multiple deep ulcers at the esophagus. Her symptoms resolved completely after stopping alendronate. A follow-up esophagogastroduodenoscopy 6 weeks later revealed complete healing of the ulcers.
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