Korean J Gastrointest Endosc.  1999 Apr;19(2):300-305.

Pyoderma Gangrenosum in Ulcerative Colitis

• Seok JH
• Park JC
• Kwun SW
• Choi JS
• Kim JH
• Kim YS
• Kim TN
• Chung MK

Abstract

Ulcerative colitis is an inflammatory disorder that affects the rectum and extends proximally to affect a variable extent of the colon. The major symptoms of ulcerative colitis include diarrhea, rectal bleeding, the passage of mucus, and abdominal pain. Ulcer-ative colitis also may be complicated by many local and systemic disorders as extrain-testinal manifestations. Pyoderma gangrenosum is the most severe dermatologic com-plication associated with ulcerative colitis. It is a painful , chronic, ulcerating skin disease of unknown cause. Diagnosis is clinical, there being no accepted histological diagnostic criteria. Conventional therapy is empirical, usually with high dose corticosteroids, but var-ious other agents have been tried with occasional success including topical antibiotics, cyclosporine, disodium cromoglycate, and dapsone. This patient was treated with high dose corticosteroid (prednisolone 1 mg/kg/day) and discharged with clinical improvement. So we report this case with a literature review.

Keyword

Ulcerative colitis; Pyoderma gangrenosum; Steroid

MeSH Terms

Abdominal Pain
Adrenal Cortex Hormones
Anti-Bacterial Agents
Colitis
Colitis, Ulcerative*
Colon
Cromolyn Sodium
Cyclosporine
Dapsone
Diagnosis
Diarrhea
Hemorrhage
Humans
Mucus
Pyoderma Gangrenosum*
Pyoderma*
Rectum
Skin Diseases
Ulcer*
Adrenal Cortex Hormones
Anti-Bacterial Agents
Cromolyn Sodium
Cyclosporine
Dapsone