Korean J Nosocomial Infect Control.  1998 Dec;3(2):97-100.

Viral inactivation of disinfectant Tego-51(R)

Affiliations
  • 1Department of Cinical Pathology, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND
Tego-51(R), one of the amphoteric surfactants, has been considered as an effective disinfectant having both bactericidal and fungicidal effect. The author evaluated inactivation effect of Tego-51(R) on viruses causing disease in humans.
METHODS
Influenza virus B, respiratory syncytial virus (RSV), herpes simplex virus 1 (HSV-1), adenovirus and echovirus 30 were exposed to diluted Tego-51(R) solution (1% and 0.1%) for 5, 10 and 30 minutes respectively and were inoculated onto the following cells: Influenza virus B, MDCK; RSV, HEp-2; HSV-1, HEp-2; adenovirus, Vero; and echovirus 30, RD. After incubation for 5 to 6 days, viral infection was identified with indirect immunofluorescent methods.
RESULTS
Influenza virus B, RSV and HSV-1 which are enveloped viruses were inactivated after exposure of the viruses to Tego-51(R) for 5 minutes. Non-enveloped adenovirus and echovirus 30 were not inactivated after exposure for 30 minutes.
CONCLUSIONS
Tego-51(R) appears to be effective in inactivation of enveloped viruses at concentrations used for disinfection of pathogenic bacteria and fungi.

Keyword

Virus; Inactivation; Enveloped; Tego-51(R)

MeSH Terms

Adenoviridae
Bacteria
Disinfection
Enterovirus B, Human
Fungi
Herpesvirus 1, Human
Humans
Orthomyxoviridae
Respiratory Syncytial Viruses
Surface-Active Agents
Virus Inactivation*
Surface-Active Agents
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