Korean J Obstet Gynecol.  2007 Nov;50(11):1569-1575.

A case of successful treatment of stroke with intracardiac thrombi in a patient with severe ovarian hyperstimulation syndrome

• Kim SR
• Kim EJ
• Kim JS
• Koo YH
• Kim SH
• Chae H
• Kim CH
• Kang BM

Abstract

Thromboembolism is a rare complication of ovarian hyperstimulation syndrom (OHSS). According to the numerous reports, it most commonly occurs in upper extremities, head, and neck vein. It is also well known that acute cerebral infarction, once occurred, is mainly caused by the occlusion of large arteries, especially middle cerebral artery (MCA) in most cases. Administration of heparin has been considered as the best treatment option, but many studies have been reporting successful treatment results from administrating thrombolytics in patients with cerebral infarction. Although administration of thrombolytics is invasive and has some potential side effects including bleeding or hematoma, it still has been used for treating patients with cerebral infarction. We report a case of patient with intracardiac thrombi and manifested symptoms of acute cerebral infarction originally caused by OHSS followed by the occlusion of MCA. We administered thrombolytics within one and half hours of showing left hemiparesis caused by the occlusion of right MCA, and identified reperfusion of MCA. There was no evidence of complications associated with the administration of thrombolytics on CT scan, which was taken 24 hours later. Thrombi in IVC, right atrium, and right ventricle were found on chest CT with pleural effusion, but soon were disappeared after administrating heparin anticoagulation. We report this case to show that thrombolytics and anticoagulation can be safely used to treat a patient with cerebral infarction and thrombi caused by OHSS without any side effects or complications.

Keyword

Ovarian hyperstimulation syndrome; Stroke; Thrombolytics; Intracardiac thrombus

MeSH Terms

Arteries
Cerebral Infarction
Female
Head
Heart Atria
Heart Ventricles
Hematoma
Hemorrhage
Heparin
Humans
Middle Cerebral Artery
Neck
Ovarian Hyperstimulation Syndrome*
Paresis
Pleural Effusion
Reperfusion
Stroke*
Thromboembolism
Tomography, X-Ray Computed
Upper Extremity
Veins
Heparin