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Immunosuppressive Drug Measurement by Liquid Chromatography Coupled to Tandem Mass Spectrometry: Interlaboratory Comparison in the Korean Clinical Laboratories

Kim HK, Park HD, Lee SG, Chae H, Song SH, Lee YW, Yun YM, Ahn S, Kim S, Lee SM, Lee SY, Chun S, on behalf of the Clinical Mass Spectrometry Research Committee of the Korean Society of Clinical Chemistry

Background: Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is increasingly used for immunosuppressive drug tests. However, most LC-MS/MS tests are laboratory-developed and their agreement is unknown in different Korean...
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Metabolically Healthy Obesity Is Associated with an Increased Risk of Colorectal Adenoma Occurrence Diagnosed by Surveillance Colonoscopy

Chae H, Yang HJ, Park SK, Jung YS, Park JH, Park DI, Sohn CI

Background/Aims: The risk of recurrence of colorectal adenoma among obese individuals without metabolic abnormalities or in those with metabolically healthy obesity is largely unexplored.Therefore, we longitudinally investigated the risk of...
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Trends in Chemotherapy Patterns and Survival of Patients with Advanced Gastric Cancer over a 16-Year Period: Impact of Anti-HER2–Targeted Agent in the Real-World Setting

Koo DH, Ryu MH, Lee MY, Chae H, Kim EJ, Moon MS, Kang YK

Purpose This study aimed to evaluate the survivals of patients with metastatic or recurrent gastric cancer (MRGC) over a period of 16 years and to investigate the recent changes in chemotherapy...
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Targeted Next-Generation Sequencing of Plasma CellFree DNA in Korean Patients with Hepatocellular Carcinoma

Chae H, Sung PS, Choi H, Kwon A, Kang D, Kim Y, Kim M, Yoon SK

Background: Hepatocellular carcinoma (HCC) is the second-most-common cause of cancer-related deaths worldwide, and an accurate and non-invasive biomarker for the early detection and monitoring of HCC is required. We assessed...
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MicroRNAs Related to Cognitive Impairment After Hearing Loss

Mun SK, Chae H, Piao XY, Lee HJ, Kim YK, Oh SH, Chang M

Objectives. Our research group has previously demonstrated that hearing loss might be a risk factor for synaptic loss within the hippocampus and impairment of cognition using an animal model of...
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NF1 Variant Spectrum in Korean Patients with Neurofibromatosis Type 1 Disorder

Kang H, Lee J, Park J, Yim J, Chae H, Kim Y, Kim M

Background: Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant disorders in humans, and many different variants in the NF1 gene have been observed. The aim of...
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Robot-Assisted Laparoscopic Surgery for Pelvic Organ Prolapse among Peri- and Post-Menopausal Women

 Kim J, Lee S, Lee ES, Kim S, Chae H

For patients with apical compartment pelvic organ prolapse (POP), abdominal sacrocolpopexy has been considered superior to the vaginal approach in terms of less dyspareunia and decreased risk of recurrence. Robot-assisted...
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Prenatal Genetic Diagnosis of Congenital Nephrotic Syndrome

Seo JM, Kim SY, Park IY, Chae H, Kim M

Congenital nephrotic syndrome (CNS) of the Finnish type is an autosomal recessive disorder caused by mutations in the gene encoding nephrin (NPHS1). A 31-year-old primigravida woman from the Philippines was...
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A Case of Intralabyrinthine Schwannoma and Literature Review of the Cases Reported Previously in Korea

Jeon H, Chae H, Lee H, Seo YJ

Vestibular schwannoma is a rare tumor that develops in the nerves responsible for vestibular function and hearing. It usually affects middle-aged people, and is diagnosed by hearing and imaging tests....
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The Time of Return to Play after Surgery for Chronic Lateral Ankle Instability in Athletes: A Systematic Review

Kim J, Yu J, Chae H

Purpose: The study aimed to assess the average time to return to play following surgery for chronic lateral ankle instability in athletes. Methods: A literature search was conducted (1976 to 2019)...
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Clinical Validity of Next-Generation Sequencing Multi-Gene Panel Testing for Detecting Pathogenic Variants in Patients With Hereditary Breast-Ovarian Cancer Syndrome

Yoo J, Lee GD, Kim JH, Lee SN, Chae H, Han E, Kim Y, Kim M

BACKGROUND: Hereditary breast and ovarian cancer syndrome (HBOC) is caused by pathogenic variants in BRCA and other cancer-related genes. We analyzed variants in BRCA gene and other cancer-related genes in...
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Thick “Swiss Cheese” Appearance of Uterine Endometrium in Postmenopausal Women with Different Gynecologic Conditions

Ko Y, Chung J, Lee SR, Kim SH, Chae H, Kang BM

OBJECTIVES: To uncover gynecologic conditions with similar transvaginal sonographic findings of thick uterine endometrium with honeycomb appearance in pre-and postmenopausal women. METHODS: We retrospectively reviewed cases of patients with endometrial tissue...
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Use of Liquid Chromatography-Tandem Mass Spectrometry for Clinical Testing in Korean Laboratories: a Questionnaire Survey

Chae H, Cho SE, Park HD, Chun S, Lee YW, Yun YM, Song SH, Lee SG, Lee K, Song J, Lee SY, On behalf of the Clinical Mass Spectrometry Research Committee of Korean Society of Clinical Chemistry

BACKGROUND: The use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) has substantially increased in clinical laboratories worldwide. To assess the status of clinical LC-MS/MS testing in Korean laboratories, a questionnaire survey...
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A Questionnaire Survey on General Status and Opinions about Clinical Mass Spectrometric Analysis in Korea (2018)

Cho SE, Chae H, Park HD, Chun S, Lee YW, Yun YM, Song SH, Lee SG, Lee K, Song J, Lee SY, On behalf of the Clinical Mass Spectrometry Research Committee of Korean Society of Clinical Chemistry

The Clinical Mass Spectrometry Research Committee (CMSRC), in affiliation with the Korean Society of Clinical Chemistry (KSCC), conducted a questionnaire survey on opinions about the general status of clinical mass...
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Systematic Review on the Efficacy and Safety of Erenumab for the Prevention of Migraine

Son P, Chae H, Ji E, Yoo BK

OBJECTIVE: This study aimed to provide efficacy and safety information on the use of erenumab for prevention of episodic and chronic migraines. METHODS: The keywords “Erenumab and migraine” were used to...
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Relationships between Obesity, Body Image Perception, and Weight Control in Adult Women

Chae H

PURPOSE: The purpose of this study was to investigate the relationship between obesity, body image perception, and weight control for obesity management in adult women. METHODS: The subjects of this study...
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Chromosomal Microarray Analysis as a First-Tier Clinical Diagnostic Test in Patients With Developmental Delay/Intellectual Disability, Autism Spectrum Disorders, and Multiple Congenital Anomalies: A Prospective Multicenter Study in Korea

Jang W, Kim Y, Han E, Park J, Chae H, Kwon A, Choi H, Kim J, Son JO, Lee SJ, Hong BY, Jang DH, Han JY, Lee JH, Kim SY, Lee IG, Sung IK, Moon Y, Kim M, Park JH

BACKGROUND: To validate the clinical application of chromosomal microarray analysis (CMA) as a first-tier clinical diagnostic test and to determine the impact of CMA results on patient clinical management, we...
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Chimeric Antigen Receptor T-Cell Therapy for Diffuse Large B-Cell Lymphoma

Chae H, Yoon DH

CD19 chimeric antigen receptor T-cell (CAR-T) therapy, a genetically engineered cell therapy, showed unprecedented efficacy in the treatment of relapsed or refractory diffuse large B-cell lymphoma. Two agents, axicabtagene ciloleucel...
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Nonautoimmune congenital hyperthyroidism due to p.Asp633Glu mutation in the TSHR gene

Cho WK, Ahn MB, Jang W, Chae H, Kim M, Suh BK

Most cases of congenital hyperthyroidism are autoimmune forms caused by maternal thyroid stimulating antibodies. Nonautoimmune forms of congenital hyperthyroidism caused by activating mutations of the thyrotropin receptor (TSHR) gene are...
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Bleeding after Taking Dual Antiplatelets and NSAID Concurrently

Seo J, Choi J, Son P, Lee S, Chae H, Kang G, Ji E

When stenting is applied to treat myocardial infarction, antiplatelet agents are administered to prevent thrombosis, which increases the risk of bleeding. Patients with myocardial infarction are also more likely to...
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