Korean J Obstet Gynecol.  2002 Aug;45(8):1311-1316.

The Expressions of Matrix Metalloproteinase-9 and Tissue Inhibitors of Metalloproteinase-1 in Scar Endometriosis and Full Term Endometrium

• Cho CH
• Koh SB

Abstract

OBJECTIVE
Endometriosis in a surgical scar following cesarian section is rare condition. And its pathogenesis has not been well established. The purpose of this study is to observe the expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinase-1 (TIMP-1) in scar endometriosis and full term endometrium during cesarian section.
METHODS
Nineteen scar endometriotic tissue and ten full term pregnant endometrium during cesarian section were investigated by immunohistochemical stain for MMP-9 and TIMP-1.
RESULTS
The MMP-9 was expressed in eleven of nineteen scar endometriotic tissue (57.9%) and eight of ten full term pregnant endometrium (80.0%). The TIMP-1 was not expressed in both scar endometriotic tissue and full term pregnant endometrium.
CONCLUSION
These results suggest that the relationship between MMP-9 and TIMP-1 might play a role of pathogenesis of scar endometriosis.

Keyword

Endometriosis; Endometrium; Abdominal scar; MMP-9; TIMP-1

MeSH Terms

Cicatrix*
Endometriosis*
Endometrium*
Female
Matrix Metalloproteinase 9*
Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinase 9
Tissue Inhibitor of Metalloproteinase-1