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Plasma Levels and Diagnostic Utility of Macrophage Colony-Stimulating Factor, Matrix Metalloproteinase-9, and Tissue Inhibitor of Metalloproteinases-1 as New Biomarkers of Breast Cancer

Lawicki S, Glazewska , Sobolewska M, Bedkowska , Szmitkowski M

BACKGROUND: Macrophage colony-stimulating factor (M-CSF), matrix metalloproteinase-9 (MMP-9), and its specific tissue inhibitor - tissue inhibitor of metalloproteinases-1 (TIMP-1) may play an important role in the pathogenesis and spread of...
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Prominent IL-12 Production and Tumor Reduction in Athymic Nude Mice after Toxoplasma gondii Lysate Antigen Treatment

Pyo KH, Jung BK, Xin CF, Lee YW, Chai JY, Shin EH

Toxoplasma gondii is an intracellular protozoan parasite that causes a Th1 cellular immunity. Our previous study showed that T. gondii lysate antigen (TLA) treatment in S180 tumor-bearing mice resulted in...
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Curcumin Induced Decreased Expression of Type I Collagen in Human Skin Fibroblast Through Down-regulation of Smad2/3 Expressions

Ryu HW, Kim SP, Lee KS, Cho JW

  • KMID: 2247498
  • Korean J Dermatol.
  • 2012 Jan;50(1):1-7.
BACKGROUND: Imbalance among TGF-beta/Smad pathway, MMP-1, and TIMP-1 expressions results in sclerotic skin disease, such as scleroderma, hypertrophic scar, and keloids. Curcumin, a phytochemical extracted from the rhizomes of Curcuma...
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The Efficacy of Shikonin on Cartilage Protection in a Mouse Model of Rheumatoid Arthritis

Kim YO, Hong SJ, Yim SV

The potential therapeutic action of shikonin in an experimental model of rheumatoid arthritis (RA) was investigated. As a RA animal model, DBA/1J mice were immunized two times with type II...
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The mRNA expression of MMP-1, TIMP-1, TGF-beta1 in gingival keratocytes from gingival hyperplasia induced by cyclosporine A

Kang HS, Lee JS, Bing JH, Park CJ, Im JJ, Hwang KG, Shim KS

  • KMID: 2190164
  • J Korean Assoc Oral Maxillofac Surg.
  • 2008 Aug;34(4):405-411.
PURPOSE: Cyclosporine A (CsA) is a versatile immunosuppresive agent used to prevent graft rejection syndrome and treat autoimmune disease. One of the major side effects associated with CsA is the...
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The Influence of Diabetes on of PGE2, MMP-14 and TIMP Expressions in Human Chronic Periodontitis

Kim SW, Park JW, Suh JY, Lee JM

PURPOSE: The purposes of this study were to compare and quantify the expression of PGE2, MMP-14 and TIMP-1 in the gingival tissues of patients with type 2 diabetes mellitus and...
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The comparison of inflammatory mediator expression in gingival tissues from human chronic periodontitis patients with and without type 2 diabetes mellitus

Joo SD, Lee JM

No abstract available.
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SP1 Mediates IFNgamma-induced TIMP-1 Transctription in C6 Astroglioma Cells

Shin JH, Kim SW, Kim ID, Lee MH, Lee JK

  • KMID: 2092892
  • Korean J Anat.
  • 2007 Jun;40(2):77-83.
Tissue inhibitors of metalloproteinases (TIMPs) comprise a family of secreted multifunctional proteins that consists of four members (TIMP-1 to TIMP-4). TIMPs are all major inhibitors of most matrix metalloproteinases (MMPs)....
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The Effects of Dehydroepiandrosterone-pyruvate on Human Osteoarthritic Chondrocytes

Lee MC, Ji JH, Kim WY, Do JH, Kim YM

  • KMID: 1575226
  • J Korean Orthop Res Soc.
  • 2006 Oct;9(2):153-164.
PURPOSE: To investigate the in vitro effects of Dehydroepiandrosterone (DHEA)-pyruvate on human osteoarthritic chondrocytes. METHODS: Chondrocytes isolated from human osteoarthritic knee cartilage were three-dimensionally cultured in Alginate beads. Cells were treated...
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The mRNA expression of growth factors in fibroblast from gingival hyperplasia induced by cyclosporine A

Kim YM, Hwang KG, Lee JS

  • KMID: 2058621
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2006 Sep;28(5):445-453.
Cyclosporine A (CsA) is a powerful immunosuppresive agent used to prevent graft rejection of organ and treat autoimmune disease. One of the major side effects associated with CsA treatment is...
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Expression of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 after Administration of Endotoxin in Diabetic Rats

Seo KH, Choi JS, Na JO, Uh ST, Kim YH, Park CS

BACKGROUND: An acute lung injury(ALI) is characterized by the recruitment, activation, and apoptosis of inflammatory cells, numerous products released by inflammatory cells such as reactive oxygen species, inflammatory mediators, and...
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MMP and TIMP production in periodontal ligament fibroblasts stimulated by Prevotella nigrescens lipopolysaccharide

Yang WK, Lee W, Kim MR, Son HH

  • KMID: 2416536
  • J Korean Acad Conserv Dent.
  • 2005 Sep;30(5):372-384.
The purpose of this study was to monitor the secretion of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) by human periodontal ligament (PDL) fibroblasts stimulated with Prevotella nigrescens...
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The growth factors expression of cyclosporine induced gingival overgrowth

Kim YJ, Hwang KG, Oh Y, Paik SS, Shim KS

  • KMID: 2005032
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2005 Sep;27(5):438-445.
Cyclosporine A(CsA) is a powerful immunossuppresive agent used to prevent graft rejection of organ and treat autoimmune disease. One of the major side effects associated with CsA treatment is the...
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A Comparison of Expressions of MMP-3, MMP-7, TIMP-1 and Apoptosis in Keratoacanthoma and Squamous Cell Carcinoma

Kim SY, Kim SH, Choi YW, Myung KB

  • KMID: 2302644
  • Korean J Dermatol.
  • 2005 Apr;43(4):489-495.
BACKGROUND: Keratoacanthoma (KA) is a unique neoplasm, usually accompanied by rapid growth and regression, and the histologic findings resemble those of squamous cell carcinoma (SCC). Histologic differentiation of KA and...
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MMP-1 and TIMP-1 production in MG-63 cells stimulated with Prevotella nigrescens lipopolysaccharide

Yang WK, Kim MR, Shon WJ, Lee IB, Cho BH, Um CM, Son HH

The purpose of this study is to monitor the secretion of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) produced by human osteosarcoma cell line (MG63) stimulated with Prevotella...
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Alteration of airway hyperresponsiveness and expression of MMP-9 and TIMP-1 in bronchial tissue by nebulized IFN-gamma in murine model of asthma

Lee YM, Kim YK, Park JK, Suh J, Kim KU, Kim DJ, Uh ST, Kim YH, Park CS

  • KMID: 2178418
  • J Asthma Allergy Clin Immunol.
  • 2003 Dec;23(4):788-799.
BACKGROUND: A bronchial asthma is characterized with airway inflammation, tissue damage, and deposition of extracellular matrix protein, which may be mediated, in part, through released matrix metalloproteinase-9 (MMP-9) and tissue...
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Expression of CD44, MMP-2, MMP-9 and TIMP-1 in tongue squmous cell carcinoma

Lee SH, Pyo SW, Kim YS, Choie MK

  • KMID: 2118344
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2003 Jul;25(4):273-282.
Adhesion molecules and proteinases play an important role in the invasion and metastasis of a malignant tumor. However, there have not been many studies on tongue squamous cell carcinoma, the...
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Increased Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Levels in the Cerebrospinal Fluid from Children with Aseptic Meningitis

Yang JH, Park MH, Shim JY, Jung HL, Park MS, Keum DH

  • KMID: 1606819
  • J Korean Pediatr Soc.
  • 2003 Jun;46(6):548-553.
PURPOSE: Matrix metalloproteinase(MMP)-9 is known to breakdown the blood-brain barrier by degrading the extracellular matrix of the subendothelial basement membrane in meningitis. Tissue inhibitor of metalloproteinase(TIMP)-1, a known inhibitor of...
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The Expressions of Matrix Metalloproteinase-9 and Tissue Inhibitors of Metalloproteinase-1 in Scar Endometriosis and Full Term Endometrium

Cho CH, Koh SB

  • KMID: 1925514
  • Korean J Obstet Gynecol.
  • 2002 Aug;45(8):1311-1316.
OBJECTIVE: Endometriosis in a surgical scar following cesarian section is rare condition. And its pathogenesis has not been well established. The purpose of this study is to observe the expressions...
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The Relationship Between Expression of Matrix Metalloproteinases(MMPs)-2, 9 and Tissue Inhibitors of Metalloproteinase (TIMP)-1, 2 and Survival Time in Resected Non-Small Cell Lung Cancer

Kim HR, Yang SH, Jeong ET

  • KMID: 2318377
  • Tuberc Respir Dis.
  • 2002 May;52(5):453-462.
BACKGROUND: Matrix metalloproteinases (MMPs) are a large family of proteolytic enzymes, which are in volved in the degradation of many different components of the extracellular matrix. There is increasing evidence...
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