Korean J Dermatol.  1976 Jun;14(2):91-95.

A Study of Anctiviy with CAstsnea Crenata Flos

• Lee CW
• Kim HS

Abstract

There are many herbs used in the treatment of dermatophytosis as home medicine and Castanea crenata Flos (C.C.F.) is one of that used in Kyung gi-do district. With that regard we tried to examine in vitro antifungal activity of the C.C.F. with its water extract and alcohol extract as the test materials. Until now many authors have studied the antifungal activity with several plant extracts, as like the alcohol extracts of Zanthoxylum piperatum Fructus and Berberis Korea palibin or Fennel oil, and reported that these plant extrscts or essential oiI have good antifungal activities in vitro and in vivo. On that they said that the principal fractions those have strong fungistatic activity were all alikely the fatty acids chemically similar with the well known undecylenic acid. At this in vitro experiment the extracts of C.C.F. were diluted. serially in the Sabourauds dextrose agar and certain portions of fungi (the strains of Trichophyton (Tr.) mentagrophytes and Tr. rubrum) were transplanted into each medium containing different concentrations of test materials then observed its growth for 2 weeks at room temperature. After that we measured the sizes of colony grown in various conditions and compired with that of the normal medium to determine the fungistatic effectiveness. As the result, in the view of the colony sizes, Tr. mentagrophytes and Tr. rubrum equally revealed marked inhibition of its growth only in the media with water extract over the concentration of 10mg/ml in the mediurn, and the critical fungistatic dilution was 20 mg/ml. We could not identified the principal fraction in the water extract of C.C.F.which exhibited antifungal activity. In the comparison of the critical fungistatic dilution with the alcohol extract of Zanthoxylum piperaturn Fructus and Fennel oil, water extract of C.C.F. required tenfold higher concentration for the same effect. However in regarding the utilizing habits of C.C.F. in horne medicine, as topical wet dressing with water boiled solution, we might expect its effect practically. iVow there are problems to be investigated about the chemical natures and physical properties of the C.C.F. and for the antifungal fractions of it, in addition further in vivo study we thought would be interesting.

MeSH Terms

Agar
Animals
Bandages
Berberis
Fatty Acids
Foeniculum
Fungi
Glucose
Horns
Korea
Plant Extracts
Plants
Tinea
Trichophyton
Water
Zanthoxylum
Agar
Fatty Acids
Glucose
Plant Extracts
Water