Korean J Phys Anthropol.  2001 Jun;14(2):159-168.

Radiation -induced Congenital Anomalies in the Rat Fetuses

• Lee WJ
• Han SR
• Jeong O
• Kim SI
• Cho MJ
• Kim WS

Abstract

X -ray irradiation induces various congenital anomalies in the human fetuses and experimental animals. The action mechanism of teratogenesis, however, still not known completely. Furthermore, the dynamics of teratogenesis according to the developmental stages are so great that complete unveiling the teratogenic action mechanism of radiation is nearly impossible. And, it is necessary to make the experimental model for the study on the damages caused by electromagnetic field, recently. In this study, the Sprague -Dawley rats were irradiated 2 Gy once on the GD 10.7, and observed the congenital anomalies of the fetuses on GD 17.5, grossly and light microscopically. The results were as follows ; 1. There was no significant difference in the survival rate between control and irradiated groups. However, mean body weight of the experimental group decreased significantly compared to control group. 2. X -irradiation -induced congenital anomalies were eye anomalies such as unilateral and/or bilateral anophthalmia, microphthalmia, and aphakia, hemorrhagic plaques on the head, tail anomalies such as short tail and curved tail, and posterior limb anomalies. 3. Posterior limb anomalies were all ecrodactyly, such as 4 -digit anomaly, 3 -digit anomaly, and cleft foot. In the sidedness of anomalies, right side showed greater dominance than left.

Keyword

x -radiation; Congenital anomalies

MeSH Terms

Animals
Anophthalmos
Aphakia
Body Weight
Electromagnetic Fields
Extremities
Fetus*
Foot
Head
Humans
Microphthalmos
Models, Theoretical
Rats*
Survival Rate
Tail
Teratogenesis