Korean J Urol.  2001 Nov;42(11):1159-1162.

The Effectiveness of Combined Imipramine and Desmopressin in the Treatment of Enuresis

• Kim SJ
• Kim WS
• Chung JY

Abstract

PURPOSE: To evaluate the effectiveness of combined imipramine and desmopressin in the treatment of enuretic patients who did not respond to imipramine.
MATERIALS AND METHODS
Initially 83 children were treated with imipramine, as a primary treatment for 4 weeks. To 38 patients who did not respond to imipramine, low-dose desmopressin were additionally given per os. During the study, the patients were divided into three categories; 1) complete responder with 0-1 wet nights per week, 2) intermediate responders with 2-3 wet nights per week and 3) non-responders with more than three wet nights per week.
RESULTS
The response rate of combined imipramine and desmopressin was 73.7% (28/38) and 11 patients out of 28 patients showed recurrence after the discontinuation of medication. No serious side effects were observed.
CONCLUSIONS
Combined therapy was effective in enuretic children who did not respond to imipramine treatment.

Keyword

Enuresis; Imipramine; Desmopressin; Combined therapy

MeSH Terms

Child
Deamino Arginine Vasopressin*
Enuresis*
Humans
Imipramine*
Recurrence
Deamino Arginine Vasopressin
Imipramine