Study on Serum and Urinary Calcium Level and Serum Parathyroid Hormone in Patients with Urinary Stone

Jeon, Young Hwan; Yun, Neung Su

Abstract

Urinary tract calculi are among the earliest documented afflictions of man but much remains to be learned about the causes and prevention of this common disease. We estimated the serum concentration and urinary excretion of calcium in 65 stone-formers, comparing to those 21 controls. Additionally, serum parathyroid hormone level in 38 stone-formers was estimated. The results were as follows: 1. Serum calcium levels of stone formers were significantly higher than those of controls in total, male and female. 2. Urinary calcium levels of stone formers were significantly higher than those of controls in total, male and female. 3. Hypercalcemia was significantly more frequent for stone-formers in total and male, but not in female. 4. Hypercalcemia was significantly more frequent for stone-formers in total, but not in male and female. 5. The incidence of stone-formers, in whom normocalcemia and normocalciuria, was significantly less than that of controls. 6. Serum parathyroid hormone levels of stone formers were significantly higher than those of control in total and female, but not in male. 7. The elevated serum parathyroid hormone was more frequent in stone formers, but not significant statistically. These results suggest the possibility that metabolic disorder of calcium may play some roles in the genesis of urinary stone.