Arch Plast Surg.  2015 May;42(3):316-320. 10.5999/aps.2015.42.3.316.

Evaluating the Effectiveness of Cryopreserved Acellular Dermal Matrix in Immediate Expander-Based Breast Reconstruction: A Comparison Study

• Kim SY
• Lim SY
• Mun GH
• Bang SI
• Oh KS
• Pyon JK

• KMID: 1908405
• DOI: http://doi.org/10.5999/aps.2015.42.3.316

Abstract

BACKGROUND
CGCryoDerm was first introduced in 2010 and offers a different matrix preservation processes for freezing without drying preparation. From a theoretical perspective, CGCryoDerm has a more preserved dermal structure and more abundant growth factors for angiogenesis and recellularization. In the current study, the authors performed a retrospective study to evaluate freezing- and freeze-drying-processed acellular dermal matrix (ADM) to determine whether any differences were present in an early complication profile.
METHODS
Patients who underwent ADM-assisted tissue expander placement for two stage breast reconstruction between January of 2013 and March of 2014 were retrospectively reviewed and divided into two groups based on the types of ADM-assisted expander reconstruction (CGDerm vs. CGCryoDerm). Complications were divided into four main categories and recorded as follows: seroma, hematoma, infection, and mastectomy skin flap necrosis.
RESULTS
In a total of 82 consecutive patients, the CGCryoDerm group had lower rates of seroma when compared to the CGDerm group without statistical significance (3.0% vs. 10.2%, P=0.221), respectively. Other complications were similar in both groups. Reconstructions with CGCryoDerm were found to have a significantly longer period of drainage when compared to reconstructions with CGDerm (11.91 days vs. 10.41 days, P=0.043).
CONCLUSIONS
Preliminary findings indicate no significant differences in early complications between implant/expander-based reconstructions using CGCryoderm and those using CGDerm.

Keyword

Acelluar dermis; Tissue expander devices; Seroma

MeSH Terms

Acellular Dermis*
Drainage
Female
Freezing
Hematoma
Humans
Intercellular Signaling Peptides and Proteins
Mammaplasty*
Mastectomy
Necrosis
Retrospective Studies
Seroma
Skin
Tissue Expansion Devices
Intercellular Signaling Peptides and Proteins