J Korean Med Assoc.  2005 Apr;48(4):333-338. 10.5124/jkma.2005.48.4.333.

Medicinal Herbs can Cause Cardiovascular Side Effects

Affiliations
  • 1Department of Cardiovascular Medicine, The Catholic University of Korea College of Medicine, Kangnam St. Mary's Hospital, Korea. whitesh@catholic.ac.kr

Abstract

The concerns about the safety issues of medicinal herbs are increasing. There are typical medicinal herbs that affect the cardiovascular system such as digitalis and aconitium. Digitalis is one of the main drugs in use to manage a heart disease under the controlled safety and effectiveness. On the contrary, the Aconitium plant's roots are potentially poisonous and can cause serious complex ventricular arrhythmias and fatalities due to their low safety margin. However, the herb has been used in traditional Chinese medicine mainly to treat musculoskeletal disorders, without any safety control. Natural products including herbs derived from plants are not always safe. The use of medicinal herbs needs medical validation in terms of their safety and effectiveness through a scientific inspection and strict standardization for the quality control. Therefore it is urgent to initiate a nation-wide reporting system to timely document any side effects from medicinal herbs adversely affecting the public health.

Keyword

Medicinal herb; Cardiovascular; Side effects

MeSH Terms

Arrhythmias, Cardiac
Biological Products
Cardiovascular System
Digitalis
Heart Diseases
Medicine, Chinese Traditional
Plants, Medicinal*
Public Health
Quality Control
Biological Products

Reference

1. Hardman JG, Limbird LE, editors. Goodman and Gillman's The pharmacological basis of therapeutics. 2001. 10th ed. New York: McGraw-Hill;916–922.
2. Local Heroes. BBC2 TV Programme. 1996.
6. Chan TY, Tomlinson B, Crichley JA. Aconitine poisoning following the ingestine of Chinese herbal medicines: A report of eight cases. Aust NZ J Med. 1993. 23:268–271.
Article
10. Ellenhorn MJ, Barceloux DG. Medical toxicology. 1991. Elsevier Science Publishing Company;1242.
16. Sato H, Yamada C, Konno C, Ohizumi Y, Endo K, Hikino H. Pharmacological activities of aconitine alkaloids. Tohoku J exp Med. 1979. 128:175–187.
17. Hsu HY, Chen YP, Shen SJ, Hsu CS, Chen CC, Chang HC. Oriental Materia Medica: a concise guide. 1986. California: Oriental Healing Arts Institute;368–371.
18. Bisset NG. Arrow posionis in China. Part II. Aconitum-botany, chemistry and pharmacology. J Ethinopharmacol. 1981. 4:247–336.
Article
19. Pharmacopocia Committee. Pharmacopocia of the people's republic of China. 1990. Beijing: People's health publishing house and chemical technology press;26–28. 211–213.
20. Pepper K, Trautwein W. The effect of aconitine on the membrane current in cardiac muscle. Pflugers Arch Gesamte Physiol Menschen Tiere. 1967. 296:328–336.
Article
21. But PPH, Tai YT, Young KY. The three fetal cases of herbal aconite poisoning. Vet Hum Toxicol. 1994. 36:212–215.
22. Tai YT, But PPH, Young K, Lau CP. Cardiotoxicity after accidental herb induced aconite poisoning. Lancet. 1992. 340:1254–1256.
23. Lu HR, De Clerck F. R 56 865, a Na+/Ca2+-overload inhibitor, protects against aconitine induced cardiac arrythmias in vivo. J Cardiovasc Pharmacol. 1993. 22:120–125.
Article
24. Tsukada K, Akisuki S, Matsuoka Y, Irimajiri S. A case of aconitine poisoning acompanied by bidirectional ventricular tachycardia treated with lidocaine. Kokyu To Junkan. 1992. 40:1003–1006.
25. Muroi M, Kimura I, Kimura M. Blocking effects of hypoaconite and aconitine of nerve action potential in phrenic nerve diaphragm muscles of mice. Neuropharmacology. 1990. 29:567–572.
Article
26. Cranefield PF, Arnonson RS. Cardiac arrhythmias: The role of triggered activity and other mechanism. 1998. New York: Futura Publishing Company;388.
27. Winslow E. Hemodynamic and arrhythmogenic effect of aconitine applied to the left atria of anesthetized cats: effects of Amiodarone and atropine. J cardiovasc Pharmacol. 1981. 3:87–100.
Article
28. Kimura I, Takada M, Nojima H, Kimura M. Aconitine, a main component of aconite, increases spontaneous acetylcholine release from the frontal cerebral cortex of freely moving rats. Biol Pharm Bull. 1996. 19:1440–1442.
Article
29. Christopher H, Linden , Frederick H, Loverjoy Jr. Principle of Internal medicine. 1999. 2:2523–2529.
30. Tai YT, Lau CP, But PP, Fong PC, Li JP. Bidrectional tachycardia indu-ed by herbal aconitine poisoning. Pacing Clin Electrophysiol. 1992. 15:831–839.
31. Kolew ST, Leman P, Kite GC, Stevenson PG, Shaw D, Murray VSG. Toxicity following accidental ingestion of Aconitum containing Chinese remedy. Hum Exp Toxicol. 1996. 15:839–842.
Article
32. Fatorich DM. Aconite: A lethal Chinese herb. Ann Emerg Med. 1992. 21:309–311.
Article
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