Korean Circ J.  2005 Oct;35(10):766-772. 10.4070/kcj.2005.35.10.766.

Association of the Invasively Measured Aortic Stiffness and Coronary Artery Disease

• Park JS
• Seo JJ
• Chung JW
• Cho HJ
• Bae JW
• Kim KI
• Kang HJ
• Koo BK
• Yeon TJ
• Kim YJ
• Kim HS
• Sohn DW
• Lee MM
• Park YB
• Choi YS
• Oh BH

• KMID: 1894584
• DOI: http://doi.org/10.4070/kcj.2005.35.10.766

Abstract

BACKGROUND AND OBJECTIVES
Aortic stiffness is believed to be an important risk factor of coronary artery atherosclerosis (CAA), as it directly affects coronary perfusion. The following aspects of the invasively measured aortic pulse wave velocity (PWV) were assessed in relation to CAA: The effect of cardiovascular risk factors on PWV, the effect of PWV on the severity of CAA and on the development of the restenosis after drug-eluting stent (DES) implantation.
SUBJECTS AND METHODS
371 subjects who had undergone coronary angiography were enrolled, with all undergoing an invasive aortic PWV measurement also. 112 patients, who had undergone a DES implantation, were prospectively investigated for the effect of PWV in relation to the subsequent risk of major adverse cardiac events (MACE).
RESULTS
Among the conventional cardiovascular risk factors, an age >60 (10.79+/-4.92 vs. 8.35+/-4.02, p=0.0006), diabetes (10.97+/-4.66 vs. 9.26+/-4.70 m/sec, p=0.0118) and dyslipidemia (10.38+/-4.97 vs. 9.47+/-4.55m/sec, p=0.0421) were significantly associated with an increased PWV, but sex, smoking and hypertension were not associated with an increased PWV. The PWV was shown to be significantly associated with the severity of CAD. The odds ratio (OR) of 1m/sec increment in the PWV for an increased vessel score was 1.08 (95% confidence interval (CI): 1.03-1.13, p=0.0017). There were no differences in the incidence of MACE and the changes in the angiographic parameters between the high (>10 m/sec) and low PWV groups.
CONCLUSION
The invasively measured aortic PWV was affected by age (>60), diabetes and dyslipidemia, and also showed a strong association with the severity of CAD. The aortic PWV was not a significant risk factor for restenosis following a DES implantation.

Keyword

Coronary artery disease; Coronary restenosis; Pulse wave velocity

MeSH Terms

Atherosclerosis
Coronary Angiography
Coronary Artery Disease*
Coronary Restenosis
Coronary Vessels*
Drug-Eluting Stents
Dyslipidemias
Humans
Hypertension
Incidence
Odds Ratio
Perfusion
Prospective Studies
Pulse Wave Analysis
Risk Factors
Smoke
Smoking
Vascular Stiffness*
Smoke