Korean J Anesthesiol.  2005 Dec;49(6):888-891. 10.4097/kjae.2005.49.6.888.

Respiratory Depression Induced by Intraarticular Morphine under Total Knee Replacement: A case report

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Pochon CHA University College of Medicine, Pocheon, Korea. anesthpark@hanmail.net

Abstract

Intraarticular administration of morphine has good analgesic effect and satisfactory duration. It also shows less adverse effect of morphine than subarachnoid or epidural administration. However, high dose of morphine can cause long lasting respiratory depression. Although naloxone is effective in treatment of adverse effects of morphine, it has short duration of action. So repeating intravenous injections or continuous administration following bolus injection are recommended. We experienced a case of low dose continuous naloxone infusion for treatment of respiratory depression caused by iatraarticular morphine administration in total knee replacement surgery patient without affecting analgesic effect.

Keyword

intraarticular administration; morphine; naloxone; respiratory depression

MeSH Terms

Arthroplasty, Replacement, Knee*
Humans
Injections, Intravenous
Morphine*
Naloxone
Respiratory Insufficiency*
Morphine
Naloxone
Full Text Links
  • KJAE
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr