Korean J Clin Microbiol.
2004 Sep;7(2):171-177.
Antimicrobial Resistance of Clinically Important Bacteria Isolated from 12 Hospitals in Korea
- Affiliations
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- 1Department of Laboratory Medicine, College of Medicine, Pochon CHA University, Korea.
- 2Department of Laboratory Medicine, Keonyang University. Medicine College Korea.
- 3Department of Laboratory Medicine, Yonsei University. College of Medicine Korea. leekcp@yumc.yonsei.ac.kr
- 4Department of Laboratory Medicine, Seoul Nat. University. College of Medicine Korea.
- 5Department of Laboratory Medicine, College of Medicine Kosin University. Korea.
- 6Department of Laboratory Medicine, The Catholic University. of Korea.
- 7Department of Laboratory Medicine, Hanyang University. College of Medicine Korea.
- 8Department of Laboratory Medicine, Yonsei University. Wonju College of Medicine Korea.
- 9Department of Laboratory Medicine, Chonnam Nat. University. Medicine School, Korea.
- 10Department of Laboratory Medicine, Ajou University. College of Medicine Korea.
- 11Department of Laboratory Medicine, Sooncheonhyang University. College of Medicine Korea.
- 12Department of Laboratory Medicine, Cheju Hanmaeum Hospital, Korea.
- 13Food Microbiology Division, Center for Food Safety Evaluation, Korea Food and Drug Administration, Korea.
Abstract
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BACKGROUND: A rapid increase in antimicrobial-resistant bacteria has become a serious problem in Korea. Moreover, the antibiotic resistance problem has worsened noticeably during the past several years. The aim of this study was to determine the prevalence of resistance among frequently isolated gram-positive and -negative bacteria in Korea.
METHODS
Routine susceptibility data for medically important bacteria isolated during 6 months of 2003 were collected from 12 university and general hospital laboratories in Korea.
RESULTS
The proportion of methicillin-resistant Staphylococcus aureus (MRSA) was 66%; however, vancomycin-resistant strains were not detected. The rates of vancomycin-resistant Enterococcus faecium and penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) were 22% and 73%, respectively. The resistance rates to 3rd generation cephalosporins and monobactam were: Escherichia coli 8-12%, Klebsiella pneumoniae 18-22%, Citrobacter freundii 22-32%, Enterobacter cloacae 34-37%, and Serratia marcescens 12-21%, respectively. Imipenem resistance rates of Acinetobacter baumannii and Pseudomonas aeruginosa were 23% and 25%, respectively.
CONCLUSIONS
Antimicrobial resistant strains were already prevalent among the clinically important isolates, especially, MRSA, PNSP, and extended-spectrum cephalosporin resistant gram-negative bacilli in Korea. The imipenem-resistant rates of A. baumannii and P. aeruginosa increased, respectively, from 13% and 20% in 2002 to 23% and 25% in 2003. The results of this study will provide a basis for proper treatment of bacterial infections and prevention of spread of resistant bacteria. A continuous nationwide surveillance of antimicrobial resistance is very important and should be performed.
Keyword
MeSH Terms
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Acinetobacter baumannii
Bacteria*
Bacterial Infections
Cephalosporins
Citrobacter freundii
Drug Resistance, Microbial
Enterobacter cloacae
Enterococcus faecium
Escherichia coli
Hospitals, General
Imipenem
Klebsiella pneumoniae
Korea*
Methicillin-Resistant Staphylococcus aureus
Prevalence
Pseudomonas aeruginosa
Serratia marcescens
Streptococcus pneumoniae
Cephalosporins
Imipenem
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