Korean J Dermatol.
1995 Apr;33(2):280-286.
Clinical Study and Therapeutic Experience in Tinea Versicolor ( 3 )
Abstract
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BACKGROUND: Tinea versicolor may be treated by topical oroal antifungal drugs.
OBJECTIVE
Ihe objertive of this study was to evaluate the their, peutic effect and safety of oral itraconazole(100-200mg/day), cloconazole cream, 20% sodium chiosulfate solution, sulconazole cream and 2% ketoconazole shampoo in Tinea versicolor.
METHODS
Forty patients with Tinea versicolor were studys clinically and treated in five groups, with oral itraconazxale(100-200mg/day), cloconazole crean 20% sodium thiosulfate solution, sulconazole cream and 2% ketoconazole shampoo, from JuIIy 1991 to June, 1994. The writers also compared the results with the writers previous similar studies in 1986, 1990.
RESULTS
The average age was 29.9 years, the oldest patient were 52 year-old and the youngest patient was a 14 year-old. The ratio of male to female a 1.2: 1. The distributions of lesions was most common in the axilla(26.9%), and the other sitsuere the anterior chest(19.2%), the back(17.3%), the neck(15.4%), the upper extremites(9.6%) the abdomen(7.7%) and the lower extremites(3.9%), in order. The incidence of hyperpigrietted lesions was 76.8% and of hypopigmented lesions was 23.2%. The average duration of treatment until cure was 3.00+0.55 weeks in the oral itraconaxile treated group, 3.31+1.18 weeks in the cloconazole cream group, 3. 25+1.03 weeks in the 20%, sodium thiosulfate solution group 3.45+0.52 weeks in the sulconazole cream group and 3.40+0.33 weeks in the 2% ketoconazole shapen group. Mere were no statistically significant differences of therapeutic efficacy in each the five groups(p>0.05). Compared with the study in 1990, the average age was higher from 5.7 to 29.9 years, and the male to female ratio was slightly less, showing a relative increase in male incidence. But, there was no statistical difference in therapeutic efficacy(p>0.05).
CONCLUSION
This study was shown that the above five theraieric regimens can be used safely and simply, according to patients preferences.
