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Computational Analysis of miR-140 and miR-135 as Potential Targets to Develop Combinatorial Therapeutics for Degenerative Tendinopathy

Morya VK, Lee HW, Park CW, Park CW, Hyun JT, Noh KC

Background: Degenerative tendinopathy, a condition causing movement restriction due to high pain, highly impacts productivity and quality of life. The healing process is a complex phenomenon and involves a series...
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The Metaverse for Healthcare: Trends, Applications, and Future Directions of Digital Therapeutics for Urology

Kim EJ, Kim JY

In recent years, the emergence of digital therapeutics as a novel approach to managing conditions has garnered significant attention. This approach involves using evidence-based therapeutic interventions that are facilitated by...
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Therapeutic responses to chemotherapy or immunotherapy by molecular subtype in bladder cancer patients: A meta-analysis and systematic review

Wang S, Yuan X, Shen Z, Zhao J, Zheng B, Zhang J, Ge C

To systematically evaluate the differences in therapeutic response to chemotherapy or immunotherapy between different molecular subtypes of bladder cancer (BC). A comprehensive literature search was performed up to December 2021....
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Comorbidities and the use of comedications among patients with chronic hepatitis C in Korea: A nationwide cross-sectional study

Kwon KM, Shim JJ, Kim GA, Kim BO, Han H, Ahn HJ

Background/Aims: Chronic hepatitis C (CHC) is the second leading cause of liver-related mortality and is more prevalent in the elderly population in Korea. Decisions to initiate treatment and selection of...
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A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment

Chiu YJ, Teng YS, Chen CM, Sun YC, Hsieh-Li HM, Chang KH, Lee-Chen GJ

Alzheimer’s disease (AD) is a neurodegenerative disease with progressive memory loss and the cognitive decline. AD is mainly caused by abnormal accumulation of misfolded amyloid β (Aβ), which leads to...
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Novel therapeutic strategies for essential thrombocythemia/polycythemia vera

Yoon SY, Won JH

Myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells; these include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). MPNs are inflammatory cancers, wherein the malignant clone generates...
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Safety and efficacy of splenic artery embolization for the treatment of gastric variceal bleeding secondary to left-sided portal hypertension

Lee SY, Kim KR, Commander C

Background: Left-sided portal hypertension (LPH) is an uncommon clinical condition resulting from splenic vein stenosis/occlusion, which may cause bleeding from gastric varices. This study reviewed the long-term safety and efficacy...
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Outcomes of conventional transarterial chemoembolization using guidance software for hepatocellular carcinoma in the caudate lobe of the liver

Miyayama S, Yamashiro M, Ikeda R, Yokka A, Komiya H, Sakuragawa N

Background: To evaluate the outcomes of conventional transarterial chemoembolization (TACE) using guidance software for hepatocellular carcinoma (HCC) in the caudate lobe. Methods: Seventy-two patients with 79 treatment-naïve caudate lobe HCCs were...
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Epigenetic and Metabolic Changes in Diffuse Intrinsic Pontine Glioma

Park J, Chung C

Diffuse midline glioma (DMG), hitherto known as diffuse intrinsic pontine glioma (DIPG), is a rare and aggressive form of brain cancer that primarily affects children. Although the exact cause of...
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First Case of Atypical, Generalized Skin Rash after Transarterial Chemoembolization in a Patient with Hepatocellular Carcinoma

Lee Y, Cho E, Park CH, Yoon JH, Choi SK, Kim HO, Park C, Yun SJ

Transarterial chemoembolization (TACE) is a widely used hepatocellular carcinoma (HCC) treatment. Some cases of supraumbilical skin rash after TACE in patients with HCC have been reported. To the best of...
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Evaluation of Vancomycin TDM Strategies: Prediction and Prevention of Kidney Injuries Based on Vancomycin TDM Results

Kim B, Hwang S, Heo E, Kim Hs, Jung J, Kim ES, Kim HB, Lee K, Park JS, Song J, Lee JH, Chung JY, Song KH, Yoon S

The current guidelines for therapeutic drug monitoring (TDM) of vancomycin suggest a target 24-hour area under the curve (AUC 0-24 ) of 400 to 600 mg*h/L for serious methicillinresistant Staphylococcus...
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Delayed Chylothorax Following Blunt Chest Trauma Treated with Repeated Lymphangiography: A Case Presentation

Kim G, Noh D, Kim BM, Heo Y

Chylothorax is mostly iatrogenic, with blunt chest trauma being a rare cause. Treatment depends on the volume of drainage. Specifically, conservative treatment, such as total parenteral nutrition and pleural drainage,...
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New targeted therapies for non-small cell lung cancer

Lee EH, Kwak SH, Kim CY, Gwon HR, Kim EY, Chang YS

Background: Lung cancer is representative of a high frequency and high mortality disease and ranks at the top in incidence and mortality in Korea, when excluding thyroid cancer. In this...
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Occurrence of Metachronous Intracranial Dural Arteriovenous Fistula after Embolization of Intracranial Dural Arteriovenous Fistula: A Case Report

Kang H, Park ST

Intracranial dural arteriovenous fistula (DAVF) is an abnormal arteriovenous shunt accounting for approximately 10%–15% of all intracranial vascular malformations. Most intracranial DAVFs are solitary, but multiple lesions at different sites...
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Use of doxorubicin-eluting bead transarterial chemoembolization for unresectable hepatocellular carcinoma with portal vein invasion: a prospective study

Yu SJ, Lee YB, Cho EJ, Lee JH, Kim HC, Chung JW, Yoon JH, Kim YJ

Background/Aim: To evaluate the applicability of transarterial chemoembolization (TACE) treatment with doxorubicin drug-eluting beads (DEBs) in advanced hepatocellular carcinoma (HCC) patients with portal vein invasion (PVI). Methods: This prospective study was...
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Reflections on the Lack of Consideration of Ethnic Ancestry to Stratify Clozapine Dosing

de Leon J

This review article argues against trusting standard clozapine references, including the US package insert, because they do not include advances in the sciences of pharmacokinetics and pharmacovigilance and ignore the...
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Delayed Cerebral Ischemia after Embolization in Ruptured Spinal Arteriovenous Fistula with Subarachnoid Hemorrhage : A Case Report

Sani AF, Kurniawan D, Hamdan M, Swatan JP

Delayed cerebral ischemia (DCI) remains a devastating complication in subarachnoid hemorrhage (SAH), however, there were no present reports that is associated with a ruptured spinal arteriovenous fistula (sAVF). We would...
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Endovascular Management of Iatrogenic Vertebral Artery Pseudoaneurysm: A Case Report

Park JY, Kim S, Kang M

Iatrogenic injury of the vertebral artery during cervical spine surgery though uncommon is critical. With advances in interventional endovascular techniques, the therapeutic approach for vertebral artery injuries has changed. Nonetheless,...
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Direct Puncture of the Superficial Temporal Artery in Embolization of a Scalp Arteriovenous Fistula: A Case Report

Walker GB, Wang AP, Hadwen J, Erdenebold UE, Bebedjian R, Sullivan P, Santos MP, Chenier C, Karwaski S, Caron K, Varga G, Lyon J, Lesiuk HJ, Heran N, Heran M, Quateen A, Drake BJ, Oliveira EPD, Kontolemos M, Fahed R

We describe a minimally invasive endovascular approach to treat an arteriovenous fistula of the scalp. We performed a direct puncture of the lesion through the patient’s scalp for liquid embolic...
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Immediate surgical treatment for massive extravasation of computed tomography contrast medium in the hand: a case report

Yoo BW, Oh KS, Kim J, Kim KN, Shin HW

There are no treatment guidelines for the extravasation of contrast medium. A 71-year-old man underwent coronary artery computed tomography. When contrast medium (iohexol) was injected through the right cephalic vein,...
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